Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway: the Tromso study (vol 63, pg 214, 2019)

被引：0

作者：

Olsoy, Irene Beate ^{[1
]}

Henriksen, Stian ^{[1
,2
]}

Weissbach, Fabian H. ^{[3
]}

Larsen, Marthe ^{[4
]}

Borgen, Karoline ^{[2
]}

Abravanel, Florence ^{[5
,6
,7
]}

Kamar, Nassim ^{[5
,7
,8
]}

Paulssen, Eyvind J. ^{[9
,10
]}

Hirsch, Hans H. ^{[3
,11
,12
]}

Rinaldo, Christine Hanssen ^{[1
,2
]}

机构：

[1] Univ Hosp North Norway, Dept Microbiol & Infect Control, Tromso, Norway

[2] UiT Arctic Univ Norway, Metab & Renal Res Grp, Tromso, Norway

[3] Univ Basel, Dept Biomed, Transplantat & Clin Virol, Haus Peterspl, Basel, Switzerland

[4] Univ Hosp North Norway, Dept Clin Res, Tromso, Norway

[5] INSERM, U1043, Ctr Physiopathol Toulouse Purpan, Toulouse, France

[6] CHU Toulouse, Hop Purpan, Lab Virol, Ctr Natl Reference Virus Hepatite E, Toulouse, France

[7] Univ Paul Sabatier, Toulouse, France

[8] CHU Rangueil, Dept Nephrol & Organ Transplantat, Toulouse, France

[9] UiT Arctic Univ Norway, Dept Clin Med, Gastroenterol & Nutr Res Grp, Tromso, Norway

[10] Univ Hosp North Norway, Gastroenterol Sect, Dept Internal Med, Tromso, Norway

[11] Univ Hosp Basel, Clin Virol, Lab Med, Basel, Switzerland

[12] Univ Hosp Basel, Infect Dis & Hosp Epidemiol, Basel, Switzerland

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2019年 / 208卷 / 06期

关键词：

Enzyme-linked immunosorbent assay; Hepatitis; Hepatitis E virus; Immunoglobulin G; Seroepidemiologic study;

D O I：

10.1007/s00430-019-00626-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seroprevalence in Northern Norway. A total of 1800 serum samples from 900 women and 900 men, age 40–79 years, were randomly selected from the 21,083 participants in the 7th Tromsø Study, representing the 32,591 inhabitants of the Tromsø municipality that were ≥ 40 years. All samples were analyzed by ELISA-1 (recomWell HEV IgG). Samples testing positive or borderline, as well as a 1.5-fold excess of negative samples, were retested by ELISA-2 (DiaPro HEV IgG). If still borderline or a result discordant from ELISA-1, the sample was retested by ELISA-3 (Wantai HEV IgG) and strip-immunoassay (recomLine HEV IgG). Anti-HEV IgG was detected in 205 individuals (11.4%), yielding an estimated seroprevalence of 10.4% in the age-matched population of Tromsø. Using logistic regression analysis followed by multivariable backward elimination analysis, increasing age (OR 1.036 per year; p < 0.001) and higher education (OR 2.167; p < 0.001) were found as potential risk factors, whereas travel abroad or eating of red meat were not. Our results indicate that HEV-infection is common in Northern Norway and suggest that HEV testing should be included in the evaluation of elevated liver enzymes. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

引用

页码：887 / 887

页数：1