Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy

被引：34

作者：

Mizerska-Wasiak, Magorzata ^{[1
]}

Madyk, Jadwiga ^{[2
]}

Rybi-Szuminska, Agnieszka ^{[3
]}

Wasilewska, Anna ^{[3
]}

Miklaszewska, Monika ^{[4
]}

Pietrzyk, Jacek ^{[4
]}

Firszt-Adamczyk, Agnieszka ^{[5
]}

Stankiewicz, Roman ^{[5
]}

Bienias, Beata ^{[6
]}

Zajaczkowska, Malgorzata ^{[6
]}

Gadomska-Prokop, Katarzyna ^{[7
]}

Grenda, Ryszard ^{[7
]}

Pukajlo-Marczyk, Agnieszka ^{[8
]}

Zwolinska, Danuta ^{[8
]}

Szczepanska, Maria ^{[9
]}

Turczyn, Agnieszka ^{[1
]}

Roszkowska-Blaim, Maria ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Pediat & Nephrol, Warsaw, Poland

[2] Med Univ Warsaw, Dept Pathol, Warsaw, Poland

[3] Med Univ Bialystok, Dept Pediat & Nephrol, Bialystok, Poland

[4] Childrens Univ Hosp Cracow, Dept Pediat Nephrol, Krakow, Poland

[5] Childrens Hosp, Dept Pediat & Nephrol, Torun, Poland

[6] Med Univ Lublin, Dept Pediat Nephrol, Lublin, Poland

[7] Childrens Mem Hlth Inst, Dept Nephrol & Kidney Transplantat, Warsaw, Poland

[8] Wroclaw Med Univ, Dept Pediat Nephrol, Wroclaw, Poland

[9] Med Univ Silesia, Dept & Clin Pediat, Zabrze, Poland

来源：

PEDIATRIC NEPHROLOGY | 2015年 / 30卷 / 07期

关键词：

IgA nephropathy; IgA/C3 serum ratio; Oxford classification; Renal biopsy; Children; RENAL BIOPSY; PROGRESSION; COMPLEMENT; ACTIVATION; PROTEIN; PATHWAY; DISEASE;

D O I：

10.1007/s00467-014-3024-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The aim of this study was to evaluate the usefulness of serum immunoglobulin A/complement factor 3 (IgA/C3) ratio for predicting histological severity of kidney lesions in children with IgA nephropathy (IgAN) based on World Health Organization (WHO) and the Oxford classification (OC). We studied 89 children with IgAN with a mean age of 11.38 +/- 4.1 years (range 2-18 years). Based on available medical records, we retrospectively evaluated clinical data, IgA/C3 ratio, and kidney biopsy findings using the five-grade WHO classification and the OC The mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental sclerosis (S), tubular atrophy/interstitial fibrosis (T) (MEST) score (absent = 0, present = 1) calculated as the sum of M+E+S+T ranging from 0 to 4. Mean IgA/C3 ratio values were significantly higher (P < 0.05) in patients with M1, S1, and T1 compared with M0, S0, and T0, respectively (P < 0.05); there were no differences in the WHO classification. We found a significant positive correlation between the IgA/C3 ratio and proteinuria (r = 0.24) and determined optimal cutoff values of the IgA/C3 ratio, with a corresponding confidence interval for specific MEST scores. The IgA/C3 ratio in children with IgAN may be a useful marker of the severity of lesions found in kidney biopsy as evaluated using the OC.

引用

页码：1113 / 1120

页数：8

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