Transferrin Protein Corona-Modified CuGd Core-Shell Nanoplatform for Tumor-Targeting Photothermal and Chemodynamic Synergistic Therapies

被引:19
作者
Qi, Xiangyu [1 ]
Wang, Gang [1 ]
Wang, Peng [1 ]
Pei, Yao [1 ]
Zhang, Caiyun [1 ]
Yan, Miao [1 ]
Wei, Pengfei [1 ]
Tian, Geng [1 ]
Zhang, Guilong [1 ]
机构
[1] Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Inte, Sch Pharm, Yantai 264003, Peoples R China
基金
中国国家自然科学基金;
关键词
CuGd nanocomposite; Fenton catalysis; photothermal therapy; chemotherapy; MRI; MULTIDRUG-RESISTANCE; CANCER; GLUTATHIONE; NANOPARTICLES; ROS; NANOTECHNOLOGY; CELLS;
D O I
10.1021/acsami.1c22998
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Herein, we developed a novel transferrin protein corona (Tpc)-modified CuGd nanoplatform (Tpc-CuGd) for tumor-targeting photothermal (PT) and chemodynamic synergistic therapy. In addition, Tpc-CuGd had an ultrahigh PT conversion efficiency (similar to 55.6%) and excellent PT stability. By the calculation, the Fenton-catalytic activity of Tpc-CuGd was approximately 13.6 times that of classical ultrasmall iron oxide, endowing strong chemodynamic therapy ability in the tumor. Upon internalization of Tpc-CuGd nanoparticles (NPs), an abundance of Cu(II) was released from Tpc-CuGd and then was quickly reduced to high Fenton-catalytic activity of Cu(I) by elemental copper and cellular GSH. Next, the generated Cu(I) quickly catalyzed H2O2 into highly toxic (OH)-O-center dot, causing mitochondria damage and inducing cancer cell death. In addition, the systemic delivery of Tpc-CuGd significantly inhibited tumor growth and showed a very low toxicity. Notably, the PT effect of Tpc-CuGd NPs not only promoted their tumor inhibitory capability but also significantly restricted the continued growth of the tumor after the discontinuation of the treatment. In addition, Tpc-CuGd significantly strengthened the T-1-weighted signal of tumors and realized accurate cancer diagnosis. Therefore, this nanoplatform could be a great promising candidate for PT and chemodynamic synergistic theranostics.
引用
收藏
页码:7659 / 7670
页数:12
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