SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia

被引:370
作者
Cines, Douglas B. [1 ,2 ]
Bussel, James B. [3 ]
机构
[1] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Weill Cornell Med, Dept Pediat, New York, NY USA
关键词
D O I
10.1056/NEJMe2106315
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:2254 / 2256
页数:3
相关论文
共 12 条
[1]   Antibody-induced procoagulant platelets in severe COVID-19 infection [J].
Althaus, Karina ;
Marini, Irene ;
Zlamal, Jan ;
Pelzl, Lisann ;
Singh, Anurag ;
Haberle, Helene ;
Mehrlander, Martin ;
Hammer, Stefanie ;
Schulze, Harald ;
Bitzer, Michael ;
Malek, Nisar ;
Rath, Dominik ;
Bosmuller, Hans ;
Nieswandt, Bernard ;
Gawaz, Meinrad ;
Bakchoul, Tamam ;
Rosenberger, Peter .
BLOOD, 2021, 137 (08) :1061-1071
[2]   COVID-19 patients often show high-titer non-platelet-activating anti-PF4/heparin IgG antibodies [J].
Brodard, Justine ;
Kremer Hovinga, Johanna A. ;
Fontana, Pierre ;
Studt, Jan-Dirk ;
Gruel, Yves ;
Greinacher, Andreas .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021, 19 (05) :1294-1298
[3]   Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial [J].
Folegatti, Pedro M. ;
Ewer, Katie J. ;
Aley, Parvinder K. ;
Angus, Brian ;
Becker, Stephan ;
Belij-Rammerstorfer, Sandra ;
Bellamy, Duncan ;
Bibi, Sagida ;
Bittaye, Mustapha ;
Clutterbuck, Elizabeth A. ;
Dold, Christina ;
Faust, Saul N. ;
Finn, Adam ;
Flaxman, Amy L. ;
Hallis, Bassam ;
Heath, Paul ;
Jenkin, Daniel ;
Lazarus, Rajeka ;
Makinson, Rebecca ;
Minassian, Angela M. ;
Pollock, Katrina M. ;
Ramasamy, Maheshi ;
Robinson, Hannah ;
Snape, Matthew ;
Tarrant, Richard ;
Voysey, Merryn ;
Green, Catherine ;
Douglas, Alexander D. ;
Hill, Adrian V. S. ;
Lambe, Teresa ;
Gilbert, Sarah C. ;
Pollard, Andrew J. .
LANCET, 2020, 396 (10249) :467-478
[4]   Autoimmune heparin-induced thrombocytopenia [J].
Greinacher, A. ;
Selleng, K. ;
Warkentin, T. . E. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2017, 15 (11) :2099-2114
[5]   Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination [J].
Lee, Eun-Ju ;
Cines, Douglas B. ;
Gernsheimer, Terry ;
Kessler, Craig ;
Michel, Marc ;
Tarantino, Michael D. ;
Semple, John W. ;
Arnold, Donald M. ;
Godeau, Bertrand ;
Lambert, Michele P. ;
Bussel, James B. .
AMERICAN JOURNAL OF HEMATOLOGY, 2021, 96 (05) :534-537
[6]  
Lee K, 2009, GLOB INST, P1
[7]  
Long QX, 2020, NAT MED, V26, P845, DOI [10.1093/cid/ciaa344, 10.1038/s41591-020-0897-1]
[8]  
Ministry of Health, 2021, SING EXP COMM COVID
[9]   Platelet-activating immune complexes identified in critically ill COVID-19 patients suspected of heparin-induced thrombocytopenia [J].
Nazy, Ishac ;
Jevtic, Stefan D. ;
Moore, Jane C. ;
Huynh, Angela ;
Smith, James W. ;
Kelton, John G. ;
Arnold, Donald M. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021, 19 (05) :1342-1347
[10]  
Schultz NH, 2021, NEW ENGL J MED, V384, P2124, DOI [10.1056/NEJMoa2104840, 10.1056/NEJMoa2104882]