SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

被引：274

作者：

Pajon, Rolando ^{[1
]}

Doria-Rose, Nicole A. ^{[2
]}

Shen, Xiaoying ^{[3
]}

Schmidt, Stephen D. ^{[2
]}

O'Dell, Sijy ^{[2
]}

McDanal, Charlene ^{[3
]}

Feng, Wenhong ^{[3
]}

Tong, Jin ^{[3
]}

Eaton, Amanda ^{[3
]}

Maglinao, Maha ^{[1
]}

Tang, Haili ^{[3
]}

Manning, Kelly E. ^{[4
]}

Edara, Venkata-Viswanadh ^{[4
]}

Lai, Lilin ^{[4
]}

Ellis, Madison ^{[4
]}

Moore, Kathryn M. ^{[4
]}

Floyd, Katharine ^{[4
]}

Foster, Stephanie L. ^{[4
]}

Posavad, Christine M. ^{[5
]}

Atmar, Robert L. ^{[6
]}

Lyke, Kirsten E. ^{[7
]}

Zhou, Tongqing ^{[2
]}

Wang, Lingshu ^{[2
]}

Zhang, Yi ^{[2
]}

Gaudinski, Martin R. ^{[2
]}

Black, Walker P. ^{[2
]}

Gordon, Ingelise ^{[2
]}

Guech, Mercy ^{[2
]}

Ledgerwood, Julie E. ^{[2
]}

Misasi, John N. ^{[2
]}

Widge, Alicia ^{[2
]}

Sullivan, Nancy J. ^{[2
]}

Roberts, Paul C. ^{[8
]}

Beigel, John H. ^{[8
]}

Korber, Bette ^{[9
]}

Baden, Lindsey R. ^{[10
]}

El Sahly, Hana ^{[6
]}

Chalkias, Spyros ^{[1
]}

Zhou, Honghong ^{[1
]}

Feng, Jing ^{[1
]}

Girard, Bethany ^{[1
]}

Das, Rituparna ^{[1
]}

Aunins, Anne ^{[1
]}

Edwards, Darin K. ^{[1
]}

Suthar, Mehul S. ^{[4
]}

Mascola, John R. ^{[2
]}

Montefiori, David C. ^{[3
]}

机构：

[1] Moderna, Cambridge, MA 02139 USA

[2] NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] Duke Univ, Med Ctr, Durham, NC USA

[4] Emory Univ, Sch Med, Atlanta, GA USA

[5] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[6] Baylor Coll Med, Houston, TX 77030 USA

[7] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

[8] NIH, Bldg 10, Bethesda, MD 20892 USA

[9] Los Alamos Natl Lab, Los Alamos, NM USA

[10] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2022年 / 386卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1056/NEJMc2119912

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1088 / +

页数：5

共 5 条

[1] A preliminary report of a randomized controlled phase 2 trial of the safety and immunogenicity of mRNA-1273 SARS-CoV-2 vaccine [J].

Chu, Laurence ;

McPhee, Roderick ;

Huang, Wenmei ;

Bennett, Hamilton ;

Pajon, Rolando ;

Nestorova, Biliana ;

Leav, Brett .

VACCINE, 2021, 39 (20) :2791-2799

[2] Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase [J].

El Sahly, H. M. ;

Baden, L. R. ;

Essink, B. ;

Doblecki-Lewis, S. ;

Martin, J. M. ;

Anderson, E. J. ;

Campbell, T. B. ;

Clark, J. ;

Jackson, L. A. ;

Fichtenbaum, C. J. ;

Zervos, M. ;

Rankin, B. ;

Eder, F. ;

Feldman, G. ;

Kennelly, C. ;

Han-Conrad, L. ;

Levin, M. ;

Neuzil, K. M. ;

Corey, L. ;

Gilbert, P. ;

Janes, H. ;

Follmann, D. ;

Marovich, M. ;

Polakowski, L. ;

Mascola, J. R. ;

Ledgerwood, J. E. ;

Graham, B. S. ;

August, A. ;

Clouting, H. ;

Deng, W. ;

Han, S. ;

Leav, B. ;

Manzo, D. ;

Pajon, R. ;

Schodel, F. ;

Tomassini, J. E. ;

Zhou, H. ;

Miller, J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (19) :1774-1785

[3] Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial [J].

Gilbert, Peter B. ;

Montefiori, David C. ;

McDermott, Adrian ;

Fong, Youyi ;

Benkeser, David ;

Deng, Weiping ;

Zhou, Honghong ;

Houchens, Christopher R. ;

Martins, Karen ;

Jayashankar, Lakshmi ;

Castellino, Flora ;

Flach, Britta ;

Lin, Bob C. ;

O'Connell, Sarah ;

McDanal, Charlene ;

Eaton, Amanda ;

Sarzotti-Kelsoe, Marcella ;

Lu, Yiwen ;

Yu, Chenchen ;

Borate, Bhavesh ;

van der Laan, Lars W. P. ;

Hejazi, Nima ;

Huynh, Chuong ;

Miller, Jacqueline ;

El Sahly, Hana M. ;

Baden, Lindsey R. ;

Baron, Mira ;

De la Cruz, Luis ;

Gay, Cynthia ;

Kalams, Spyros ;

Kelley, Colleen F. ;

Andrasik, Michele P. ;

Kublin, James G. ;

Corey, Lawrence ;

Neuzil, Kathleen M. ;

Carpp, Lindsay N. ;

Pajon, Rolando ;

Follmann, Dean ;

Donis, Ruben O. ;

Koup, Richard A. .

SCIENCE, 2022, 375 (6576) :43-+

[4] Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study [J].

Hastie, Kathryn M. ;

Li, Haoyang ;

Bedinger, Daniel ;

Schendel, Sharon L. ;

Dennison, S. Moses ;

Li, Kan ;

Rayaprolu, Vamseedhar ;

Yu, Xiaoying ;

Mann, Colin ;

Zandonatti, Michelle ;

Avalos, Ruben Diaz ;

Zyla, Dawid ;

Buck, Tierra ;

Hui, Sean ;

Shaffer, Kelly ;

Hariharan, Chitra ;

Yin, Jieyun ;

Olmedillas, Eduardo ;

Enriquez, Adrian ;

Parekh, Diptiben ;

Abraha, Milite ;

Feeney, Elizabeth ;

Horn, Gillian Q. ;

Aldon, Yoann ;

Ali, Hanif ;

Aracic, Sanja ;

Cobb, Ronald R. ;

Federman, Ross S. ;

Fernandez, Joseph M. ;

Glanville, Jacob ;

Green, Robin ;

Grigoryan, Gevorg ;

Hernandez, Ana G. Lujan ;

Ho, David D. ;

Huang, Kuan-Ying A. ;

Ingraham, John ;

Jiang, Weidong ;

Kellam, Paul ;

Kim, Cheolmin ;

Kim, Minsoo ;

Kim, Hyeong Mi ;

Kong, Chao ;

Krebs, Shelly J. ;

Lan, Fei ;

Lang, Guojun ;

Lee, Sooyoung ;

Leung, Cheuk Lun ;

Liu, Junli ;

Lu, Yanan ;

MacCamy, Anna .

SCIENCE, 2021, 374 (6566) :472-+

[5] Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants [J].

Pegu, Amarendra ;

O'Connell, Sarah ;

Schmidt, Stephen D. ;

O'Dell, Sijy ;

Talana, Chloe A. ;

Lai, Lilin ;

Albert, Jim ;

Anderson, Evan ;

Bennett, Hamilton ;

Corbett, Kizzmekia S. ;

Flach, Britta ;

Jackson, Lisa ;

Leav, Brett ;

Ledgerwood, Julie E. ;

Luke, Catherine J. ;

Makowski, Mat ;

Roberts, Paul C. ;

Roederer, Mario ;

Rebolledo, Paulina A. ;

Rostad, Christina A. ;

Rouphael, Nadine G. ;

Shi, Wei ;

Wang, Lingshu ;

Widge, Alicia T. ;

Yang, Eun Sung ;

Beigel, John H. ;

Graham, Barney S. ;

Mascola, John R. ;

Suthar, Mehul S. ;

McDermott, Adrian ;

Doria-Rose, Nicole A. .

SCIENCE, 2021, 373 (6561) :1372-+

← 1 →