IDH1/2 mutations in acute myeloid leukemia

被引：0

作者：

Byun, Ja Min ^{[1
,2
]}

Yoo, Seung-Joo ^{[1
,2
]}

Kim, Hyeong-Joon ^{[3
]}

Ahn, Jae-Sook ^{[3
]}

Koh, Youngil ^{[1
,2
]}

Jang, Jun Ho ^{[4
]}

Yoon, Sung-Soo ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea

[2] Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul, South Korea

[3] Chonnam Natl Univ, Dept Hematol Oncol, Hwasun Hosp, Hwasun, South Korea

[4] Sungkyunkwan Univ, Div Hematol & Oncol, Dept Med, Samsung Med Ctr,Sch Med, 81 Irwon ro, Seoul 06351, South Korea

来源：

BLOOD RESEARCH | 2022年 / 57卷 / 01期

关键词：

Acute myeloid leukemia; IDH; Biomarker; Drug target; Korean; IDH2; MUTATIONS; PROGNOSIS; ENASIDENIB; CANCER;

D O I：

10.5045/br.2022.2021152

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mutational and epigenetic landscape of acute myeloid leukemia (AML) has become increasingly well understood in recent years, informing on biological targets for precision medicine. Among the most notable findings was the recognition of mutational hot-spots in the isocitrate dehydrogenase (IDH) genes. In this review, we provide an overview on the IDH1/2 mutation landscape in Korean AML patients, and compare it with available public data. We also discuss the role of IDH1/2 mutations as biomarkers and drug targets. Taken together, occurrence of IDH1/2 mutations is becoming increasingly important in AML treatment, thus requiring thorough examination and follow-up throughout the clinical course of the disease.

引用

页码：13 / 19

页数：7

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