Gestational Diabetes and Subsequent Growth Patterns of Offspring: The National Collaborative Perinatal Project

被引:82
作者
Baptiste-Roberts, Kesha [1 ,2 ]
Nicholson, Wanda K. [3 ]
Wang, Nae-Yuh [4 ,5 ]
Brancati, Frederick L. [4 ,6 ]
机构
[1] Penn State Univ, Sch Nursing, Hershey, PA 17033 USA
[2] Penn State Univ, Dept Publ Hlth Sci, Coll Med, Hershey, PA 17033 USA
[3] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA
[4] Johns Hopkins Univ, Dept Med, Baltimore, MD USA
[5] Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21205 USA
[6] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA
关键词
Gestational diabetes; Childhood growth; Body mass index; INTRAUTERINE EXPOSURE; BIRTH-WEIGHT; INSULIN-RESISTANCE; IN-UTERO; OBESITY; ADIPOSITY; WOMEN; RISK; MELLITUS; ORIGINS;
D O I
10.1007/s10995-011-0756-2
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Our objective was to test the hypothesis that intrauterine exposure to gestational diabetes [GDM] predicts childhood growth independent of the effect on infant birthweight. We conducted a prospective analysis of 28,358 mother-infant pairs who enrolled in the National Collaborative Perinatal Project between 1959 and 1965. The offspring were followed until age 7. Four hundred and eighty-four mothers (1.7%) had GDM. The mean birthweight was 3.2 kg (range 1.1-5.6 kg). Maternal characteristics (age, education, race, family income, pre-pregnancy body mass index and pregnancy weight gain) and measures of childhood growth (birthweight, weight at ages 4, and 7) differed significantly by GDM status (all P < 0.05). As expected, compared to their non-diabetic counterparts, mothers with GDM gave birth to offspring that had higher weights at birth. The offspring of mothers with GDM were larger at age 7 as indicated by greater weight, BMI and BMI z-score compared to the offspring of mothers without GDM at that age (all P < 0.05). These differences at age 7 persisted even after adjustment for infant birthweight. Furthermore, the offspring of mothers with GDM had a 61% higher odds of being overweight at age 7 compared to the offspring of mothers without GDM after adjustment for maternal BMI, pregnancy weight gain, family income, race and birthweight [OR = 1.61 (95%CI:1.07, 1.28)]. Our results indicate that maternal GDM status is associated with offspring overweight status during childhood. This relationship is only partially mediated by effects on birthweight.
引用
收藏
页码:125 / 132
页数:8
相关论文
共 37 条
  • [11] Prospective study of gestational diabetes mellitus risk in relation to maternal recreational physical activity before and during pregnancy
    Dempsey, JC
    Sorensen, TK
    Williams, MA
    Lee, IM
    Miller, RS
    Dashow, EE
    Luthy, DA
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2004, 159 (07) : 663 - 670
  • [12] Gestational diabetes in the United States: temporal trends 1989 through 2004
    Getahun, Darios
    Nath, Carl
    Ananth, Cande V.
    Chavez, Martin R.
    Smulian, John C.
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2008, 198 (05) : 525.e1 - 525.e5
  • [13] Effect of Treatment of Gestational Diabetes Mellitus on Obesity in the Next Generation
    Gillman, Matthew W.
    Oakey, Helena
    Baghurst, Peter A.
    Volkmer, Robert E.
    Robinson, Jeffrey S.
    Crowther, Caroline A.
    [J]. DIABETES CARE, 2010, 33 (05) : 964 - 968
  • [14] Maternal gestational diabetes, birth weight, and adolescent obesity
    Gillman, MW
    Rifas-Shiman, S
    Berkey, CS
    Field, AE
    Colditz, GA
    [J]. PEDIATRICS, 2003, 111 (03) : e221 - 226
  • [15] Hamill P. V., 1977, VITAL HLTH STAT, V11, pi
  • [16] Childhood obesity and metabolic imprinting - The ongoing effects of maternal hyperglycemia
    Hillier, Teresa A.
    Pedula, Kathryn L.
    Schmidt, Mark M.
    Mullen, Judith A.
    Charles, Marie-Aline
    Pettitt, David J.
    [J]. DIABETES CARE, 2007, 30 (09) : 2287 - 2292
  • [17] Prenatal programming of childhood overweight and obesity
    Huang, Jennifer S.
    Lee, Tiffany A.
    Lu, Michael C.
    [J]. MATERNAL AND CHILD HEALTH JOURNAL, 2007, 11 (05) : 461 - 473
  • [18] Gestational diabetes mellitus
    Jovanovic, L
    Pettitt, DJ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (20): : 2516 - 2518
  • [19] Intrauterine Exposure to Maternal Diabetes Is Associated With Higher Adiposity and Insulin Resistance and Clustering of Cardiovascular Risk Markers in Indian Children
    Krishnaveni, Ghattu V.
    Veena, Sargoor R.
    Hill, Jacqueline C.
    Kehoe, Sarah
    Karat, Samuel C.
    Fall, Caroline H. D.
    [J]. DIABETES CARE, 2010, 33 (02) : 402 - 404
  • [20] Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort
    Lawlor, D. A.
    Fraser, A.
    Lindsay, R. S.
    Ness, A.
    Dabelea, D.
    Catalano, P.
    Smith, G. Davey
    Sattar, N.
    Nelson, S. M.
    [J]. DIABETOLOGIA, 2010, 53 (01) : 89 - 97