A review of expression profiling of circulating microRNAs in men with prostate cancer

被引：27
作者：
Kelly, Brian D. [1 ,2 ]
Miller, Nicola [1 ]
Healy, Nuala A. [1 ]
Walsh, Kilian [2 ]
Kerin, Michael J. [1 ]
机构：
[1] Natl Univ Ireland Galway, Discipline Surg, Inst Clin Sci, Galway, Ireland
[2] Galway Univ Hosp, Dept Urol, Galway, Ireland
来源：
BJU INTERNATIONAL | 2013年 / 111卷 / 01期
关键词：
miRNA; circulation; prostate cancer; DOWN-REGULATION; BIOMARKERS; GENES; RNA; SIGNATURES; MIR-141; MIRNAS; SERUM;
D O I：
10.1111/j.1464-410X.2012.11244.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
MicroRNAs (miRNAs) are small non-coding RNAs that are involved in gene regulation and expression. These molecules have been implicated in the pathogenesis of several malignancies. MiRNAs have the potential to be both a tissue-and blood-based biomarker for cancer diagnosis, classification, prognosis and response to treatment. The levels of dysregulated miRNAs in the circulation of individuals make miRNAs an ideal biomarker for the detection of prostate cancer. The present study provides a comprehensive review of the expression profiling of miRNAs in the circulation of men with prostate cancer. Further research is necessary to identify if circulating miRNAs have the potential to be a biomarker for prostate cancer in clinical practice.
引用
收藏
页码：17 / 21
页数：5
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