Genetics of Heart Failure in Congenital Heart Disease

被引：11

作者：

Preuss, Christoph ^{[1
]}

Andelfinger, Gregor ^{[1
]}

机构：

[1] Univ Montreal, CHU St Justine, Serv Cardiol, Ctr Rech, Montreal, PQ, Canada

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2013年 / 29卷 / 07期

基金：

加拿大健康研究院;

关键词：

VENTRICULAR SEPTAL-DEFECTS; MYOSIN HEAVY-CHAIN; HOLT-ORAM-SYNDROME; NEONATAL HYPERTROPHIC CARDIOMYOPATHY; NORMAL CARDIAC DEVELOPMENT; BICUSPID AORTIC-VALVE; COPY-NUMBER VARIANTS; TRANSCRIPTION FACTOR; SEQUENCE VARIANTS; CONTRACTION DEFECTS;

D O I：

10.1016/j.cjca.2013.03.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure is a major problem in the patient with congenital heart disease. Normally interpreted as a sequela of surgical interventions or abnormal preoperative loading conditions, there is increasing evidence that congenital heart malformations and abnormal ventricular function can have the same underlying genetic cause. With the changing demographic characteristics and increasing complexity of care for patients with congenital heart disease, it can be anticipated that heart failure will be a rapidly growing concern in our field. In this article, we aim to give an overview of recent findings from mouse and human models that highlight shared pathways for the regulation of cardiac development and contractility, and their importance for medical care in the near future.

引用

页码：803 / 810

页数：8

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