Magnetic-Nanoparticle-Doped Carbogenic Nanocomposite: An Effective Magnetic Resonance/Fluorescence Multimodal Imaging Probe

被引：46
|
作者：
Srivastava, Sachchidanand [1 ]
Awasthi, Rishi [2 ]
Tripathi, Deepak [3 ]
Rai, Mohit K. [3 ]
Agarwal, Vikas [3 ]
Agrawal, Vinita [4 ]
Gajbhiye, Namdeo S. [1 ]
Gupta, Rakesh K. [2 ]
机构：
[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India
[2] Sanjay Gandhi Post Grad Inst Med Sci, Dept Radiodiag, Lucknow 226014, Uttar Pradesh, India
[3] Sanjay Gandhi Post Grad Inst Med Sci, Dept Immunol, Lucknow 226014, Uttar Pradesh, India
[4] Sanjay Gandhi Post Grad Inst Med Sci, Dept Pathol, Lucknow 226016, Uttar Pradesh, India
来源：
SMALL | 2012年 / 8卷 / 07期
关键词：
fluorescence; magnetic materials; magnetic resonance imaging; nanocomposites; nanoparticles; IRON-OXIDE NANOPARTICLES; I CLINICAL-EVALUATION; ONE-STEP SYNTHESIS; CONTRAST AGENT; GRAPHENE OXIDE; CARBON NANOTUBES; PARTICLES; NANODOTS; DOTS; PHOTOLUMINESCENCE;
D O I：
10.1002/smll.201101863
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and facile approach is developed to synthesize a magnetic nanoparticle (iron oxide)-doped carbogenic nanocomposite (IO-CNC) for magnetic resonance (MR)/fluorescence imaging applications. IO-CNC is synthesized by thermal decomposition of organic precursors in the presence of Fe3O4 nanoparticles with an average size of 6 nm. IO-CNC shows wavelength-tunable fluorescence properties with high quantum yield. Magnetic studies confirm the superparamagnetic nature of IO-CNC at room temperature. IO-CNC shows MR contrast behavior by affecting the proton relaxation phenomena. The measured longitudinal (r1) and transverse (r2) relaxivity values are 4.52 and 34.75 mM-1 s-1, respectively. No apparent cytotoxicity is observed and the nanocomposite shows a biocompatible nature. In vivo MR studies show both T1 and T2* contrast behavior of the nanocomposite. Fluorescence imaging indicates selective uptake of IO-CNC by macrophages in spleen.
引用
收藏
页码：1099 / 1109
页数：11
相关论文
共 50 条
  • [11] A hybrid nanoparticle probe for dual-modality positron emission tomography and magnetic resonance imaging
    Choi, Jin-sil
    Park, Jeong Chan
    Nah, Hyunsoo
    Woo, Seungtae
    Oh, Jieun
    Kim, Kyeong Min
    Cheon, Gi Jeong
    Chang, Yongmin
    Yoo, Jeongsoo
    Cheon, Jinwoo
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (33) : 6259 - 6262
  • [12] Advances in magnetic nanoparticle-based magnetic resonance imaging contrast agents
    Zhang, Huan
    Liu, Xiao Li
    Fan, Hai Ming
    NANO RESEARCH, 2023, 16 (11) : 12531 - 12542
  • [13] Biosynthetic molecular imaging probe for tumor-targeted dual-modal fluorescence/magnetic resonance imaging
    Zhao, Huaixin
    Zhao, Huiting
    Jiao, Yi
    Zhu, Yi
    Liu, Chunxia
    Li, Feng
    Wang, Yinsong
    Gu, Zi
    Yang, Dayong
    BIOMATERIALS, 2020, 256
  • [14] Manganese-Doped Carbon Dots as a Promising Nanoprobe for Luminescent and Magnetic Resonance Imaging
    Stepanidenko, Evgeniia A.
    Vedernikova, Anna A.
    Badrieva, Zilya F.
    Brui, Ekaterina A.
    Ondar, Saikho O.
    Miruschenko, Mikhail D.
    Volina, Olga V.
    Koroleva, Aleksandra V.
    Zhizhin, Evgeniy V.
    Ushakova, Elena V.
    PHOTONICS, 2023, 10 (07)
  • [15] Multimodal imaging approach to track theranostic nanoparticle accumulation in glioblastoma with magnetic resonance imaging and intravital microscopy
    Saladino, Giovanni Marco
    Mangarova, Dilyana B.
    Nernekli, Kerem
    Wang, Jie
    Annio, Giacomo
    Varniab, Zahra Shokri
    Khatoon, Zubeda
    Morais, Goreti Ribeiro
    Shi, Yifeng
    Chang, Edwin
    Pisani, Laura J.
    Tikhomirov, Grigory
    Falconer, Robert A.
    Daldrup-Link, Heike E.
    NANOSCALE, 2025, : 9986 - 9995
  • [16] Fe 3 O 4-rhodamine 6G nanoparticles: An iron enhanced pH sensitive multimodal probe for fluorescence and magnetic resonance imaging of tumor cell
    Wang, Kai
    Wang, Jian
    Xu, Xiaoguang
    Rong, Mayifei
    Lu, Liying
    Zhao, Xuemei
    Wang, Yining
    Jiang, Yong
    JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 2023, 160 : 128 - 138
  • [17] Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain
    Y. C. Zhang
    J. W. Wang
    Y. Wu
    Q. Tao
    F. F. Wang
    N. Wang
    X. R. Ji
    Y. G. Li
    S. Yu
    J. Z. Zhang
    Molecular Biology, 2022, 56 : 453 - 462
  • [18] Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain
    Zhang, Y. C.
    Wang, J. W.
    Wu, Y.
    Tao, Q.
    Wang, F. F.
    Wang, N.
    Ji, X. R.
    Li, Y. G.
    Yu, S.
    Zhang, J. Z.
    MOLECULAR BIOLOGY, 2022, 56 (03) : 453 - 462
  • [19] Characterization of nanoparticle-based contrast agents for molecular magnetic resonance imaging
    Shan, Liang
    Chopra, Arvind
    Leung, Kam
    Eckelman, William C.
    Menkens, Anne E.
    JOURNAL OF NANOPARTICLE RESEARCH, 2012, 14 (09)
  • [20] Toxicity of Magnetic Resonance Imaging Agents: Small Molecule and Nanoparticle
    Chang, Yongmin
    Lee, Gang Ho
    Kim, Tae-Jeong
    Chae, Kwon-Seok
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2013, 13 (04) : 434 - 445
12345