GSH and enzyme responsive nanospheres based on self-assembly of green tea polyphenols and BSA used for target cancer chemotherapy

被引：33
|
作者：
Zhang, Jie [1 ]
Ren, Xiuli [1 ]
Tian, Xiaohan [1 ]
Zhang, Peng [1 ]
Chen, Zhenhua [1 ]
Hu, Xun [2 ]
Mei, Xifan [1 ]
机构：
[1] Jinzhou Med Univ, Jinzhou 121001, Peoples R China
[2] Univ Jinan, Jinan 250022, Shandong, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2019年 / 173卷
基金：
中国国家自然科学基金;
关键词：
Control release; Folic acid; Stimuli-responsive; Anti-cancer; Drug delivery; MINIMALLY INVASIVE TREATMENT; DRUG-DELIVERY; PROTEIN; ACID; ANTIBACTERIAL; NANOPARTICLES; MICROSPHERES; NANOCARRIERS; CHITOSAN;
D O I：
10.1016/j.colsurfb.2018.10.037
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Developing safe and effective stimuli-responsive nanocarriers is very important for tumor chemotherapy. In this work, bovine serum albumin (BSA) and green tea polyphenol (TP) were used to prepare glutathione (GSH) and enzyme (trypsin) responsive nanocarriers for doxorubicin (DOX). These nanocarriers were further modified with folate, briefly named as DOX@BSA-TP-FA NSs. The diameter of nanocarriers was about 220 nm. The DOX loading efficiency and loading amount were 86.4% and 23.5 wt%, respectively. The cellular uptake, apoptosis, and GSH and trypsin responsive release properties of these nanocarriers were investigated.
引用
收藏
页码：654 / 661
页数：8
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