Tisagenlecleucel in Diffuse Large B-Cell Lymphoma

被引：20

作者：

Geoffrion, Dominique ^{[1
]}

Whittaker, Heather ^{[1
]}

机构：

[1] McGill Univ, Montreal, PQ, Canada

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2019年 / 380卷 / 16期

关键词：

D O I：

10.1056/NEJMc1901464

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To the Editor: In a phase 2a study of the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL), Schuster et al. (Jan. 3 issue)(1) report an overall response rate of 52% among adult patients. They observed similar levels of CD19 expression regardless of whether the patients had a response to treatment. We find it interesting that patients with a low or negative CD19 expression level before the infusion had a best-overall-response rate (49%) that was similar to that among those with an unequivocal expression level (50%). However, we . . .

引用

页码：1585 / 1585

页数：1

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