Targeting STAT5 in Leukemia Through Inhibition of Bromodomain Proteins

被引:0
|
作者
Liu, Suhu [1 ]
Walker, Sarah [1 ]
Nelson, Erik [1 ]
Cirulli, Robert [1 ]
Xiang, Michael [1 ]
Qi, Jun [1 ]
Bradner, James E. [1 ]
Frank, David [1 ]
机构
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
D O I
10.1182/blood.V120.21.399.399
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
399
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives
    Rondanin, Riccardo
    Simoni, Daniele
    Romagnoli, Romeo
    Baruchello, Riccardo
    Marchetti, Paolo
    Costantini, Cristiana
    Fochi, Sara
    Padroni, Giacomo
    Grimaudo, Stefania
    Pipitone, Rosaria Maria
    Meli, Maria
    Tolomeo, Manlio
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (18) : 4568 - 4574
  • [22] Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation
    Cordero, Alex
    Pellegrini, Pasquale
    Sanz-Moreno, Adrian
    Trinidad, Eva M.
    Serra-Musach, Jordi
    Deshpande, Chetan
    Dougall, William C.
    Pujana, Miguel Angel
    Gonzalez-Suarez, Eva
    STEM CELLS, 2016, 34 (04) : 1027 - 1039
  • [23] Targeting of STAT5 using the small molecule topotecan hydrochloride suppresses acute myeloid leukemia progression
    Li, Jiahui
    Tang, Bin
    Miao, Ying
    Li, Guihong
    Sun, Zhenliang
    ONCOLOGY REPORTS, 2023, 50 (06)
  • [24] Antisense oligonucleotides targeting human STAT5 inhibit the proliferation of human leukemia cell lines that express constitutively activated STAT5.
    Liu, RY
    Fan, C
    Whitehouse, B
    Zuckerman, KS
    BLOOD, 2000, 96 (11) : 165B - 165B
  • [25] Selective inhibition of STAT5 expression in acute myeloid leukemia cells results in potent antitumor activity
    Zhou, Tianyuan
    Guo, Shuling
    Siwkowski, Andy
    Witchell, Donna
    Pandey, Sanjay
    Monia, Brett
    MacLeod, Robert
    Kim, Youngsoo
    CANCER RESEARCH, 2009, 69
  • [26] The Role of STAT5 in HOXA9-Associated Leukemia
    Ma, Peilin
    Sun, Yuqing
    Wang, Jingya
    Song, Weihua
    Xu, Tao
    Kapur, Reuben
    Hess, Jay L.
    BLOOD, 2016, 128 (22)
  • [27] STAT5 MEDIATES MASSIVE EXPANSION OF LEUKEMIA STEM CELLS
    Heuser, M.
    Sly, L.
    Lai, C.
    Argiropoulos, B.
    Kuchenbauer, F.
    Leung, M.
    Lin, G.
    Brookes, C.
    Fung, S.
    Krystal, G.
    Humphries, R. K.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 209 - 209
  • [28] Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling
    Nam, Sangkil
    Scuto, Anna
    Yang, Fan
    Chen, WenYong
    Park, Sungman
    Yoo, Hwa-Seung
    Konig, Heiko
    Bhatia, Ravi
    Cheng, Xinlai
    Merz, Karl-Heinz
    Eisenbrand, Gerhard
    Jove, Richard
    MOLECULAR ONCOLOGY, 2012, 6 (03) : 276 - 283
  • [29] STAT3 and STAT5 Targeting for Simultaneous Management of Melanoma and Autoimmune Diseases
    Logotheti, Stella
    Puetzer, Brigitte M.
    CANCERS, 2019, 11 (10)
  • [30] Hot paper - Defining the roles of Stat5 proteins - Comment
    Halim, NS
    SCIENTIST, 2000, 14 (20): : 16 - 17