Hyper-response to Novelty Increases c-Fos Expression in the Hippocampus and Prefrontal Cortex in a Rat Model of Schizophrenia (vol 43, pg 441, 2018)

被引：0

作者：

Monfil, Tomas ^{[1
,2
]}

Vazquez Roque, Ruben Antonio ^{[3
]}

Camacho-Abrego, Israel ^{[3
]}

Tendilla-Beltran, Hiram ^{[3
]}

Iannitti, Tommaso ^{[4
]}

Meneses-Morales, Ivan ^{[5
]}

Aguilar-Alonso, Patricia ^{[6
]}

Flores, Gonzalo ^{[3
]}

Cesar Morales-Medina, Julio ^{[1
]}

机构：

[1] CINVESTAV UAT, Ctr Invest Reprod Anim, AP 62, Tlaxcala 90000, Mexico

[2] CINVESTAV, Dept Fisiol Biofis & Neurociencias, Mexico City 07360, DF, Mexico

[3] Benemerita Univ Autonoma Puebla, Lab Neuropsiquiatria, Inst Fisiol, 14 Sur 6301, Puebla 72570, Mexico

[4] KWS BioTest, Marine View Off Pk, Portishead BS20 7AW, Somerset, England

[5] Univ Nacl Autonoma Mexico, Dept Bioquim, Fac Med, Mexico City 04510, DF, Mexico

[6] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla 72570, Mexico

来源：

NEUROCHEMICAL RESEARCH | 2018年 / 43卷 / 02期

关键词：

Animal model; c-Fos; CA1 region of hippocampus; Novel environment; Prefrontal cortex; Schizophrenia;

D O I：

10.1007/s11064-018-2468-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Schizophrenia is a debilitating disorder that may have a neurodevelopmental origin. For this reason, animal models based on neonatal insults or manipulations have been extensively used to demonstrate schizophrenia-related behaviors. Among those, the neonatal ventral hippocampus lesion (nVHL) is largely used as a model of schizophrenia-related behavior as it mimics behavioral and neurochemical abnormalities often seen in schizophrenic patients including hyperlocomotion in a novel environment. To investigate the neuroanatomical basis of coding novelty in the nVHL rat, we assessed the behavioral locomotor activity paradigm in a novel environment and measured expression of c-Fos, a marker of neural activation, in brain regions involved in the process of coding novelty or locomotion. Upon reaching adulthood, nVHL rats showed hyperlocomotion in the novel environment paradigm. Moreover, in nVHL rats the expression of c-Fos was greater in the prefrontal cortex (PFC) and CA1 region of the dorsal hippocampus compared to sham rats. Whereas similar expression of c-Fos was observed in the basolateral amygdala, nucleus accumbens and dentate gyrus region of hippocampus of nVHL and sham rats. These results suggest that the nVHL disrupts the neural activity in the PFC and CA1 region of hippocampus in the process of coding novelty in the rat.

引用

页码：449 / 449

页数：1