Evaluating the effect of measles and rubella mass vaccination campaigns on seroprevalence in India: a before-and-after cross-sectional household serosurvey in four districts, 2018-2020

被引：1

作者：

Murhekar, Manoj, V ^{[1
,18
]}

Gupta, Nivedita ^{[2
]}

Hasan, Alvira Z. ^{[3
]}

Kumar, Muthusamy Santhosh ^{[1
]}

Kumar, V. Saravana ^{[1
]}

Prosperi, Christine ^{[3
]}

Sapkal, Gajanan N. ^{[6
]}

Thangaraj, Jeromie Wesley Vivian ^{[1
]}

Kaduskar, Ojas ^{[6
]}

Bhatt, Vaishali ^{[6
]}

Deshpande, Gururaj Rao ^{[6
]}

Thankappan, Ullas Padinjaremattathil ^{[6
]}

Bansal, Avi Kumar ^{[7
]}

Chauhan, Sanjay L. ^{[8
]}

Grover, Gangandeep Singh ^{[9
]}

Jain, Arun Kumar

Kulkarni, Ragini N. ^{[8
]}

Sharma, Santanu Kumar ^{[10
]}

Chaaithanya, Itta K. ^{[8
,11
]}

Kharwal, Sanchit ^{[12
]}

Mishra, Sunil K. ^{[12
]}

Salvi, Neha R. ^{[11
]}

Sharma, Sandeep ^{[7
]}

Sarmah, Nilanju P. ^{[13
]}

Sabarinathan, R. ^{[1
]}

Duraiswamy, Augustine ^{[1
]}

Rani, D. Sudha ^{[1
]}

Kanagasabai, K. ^{[1
]}

Lachyan, Abhishek ^{[11
]}

Gawali, Poonam ^{[11
]}

Kapoor, Mitali ^{[11
]}

Shrivastava, Arpit Kumar ^{[7
]}

Chonker, Saurabh Kumar ^{[7
]}

Tilekar, Bipin ^{[6
]}

Tandale, Babasaheb, V ^{[6
]}

Ahmad, Mohammad ^{[14
]}

Sangal, Lucky ^{[15
]}

Winter, Amy ^{[3
,4
]}

Mehendale, Sanjay M. ^{[16
,17
]}

Moss, William J. ^{[3
,5
]}

Hayford, Kyla

机构：

[1] Indian Council Med Res ICMR, Natl Inst Epidemiol, Chennai, India

[2] Indian Council Med Res, Div Epidemiol & Communicable Dis, New Delhi, India

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Int Vaccine Access Ctr, Dept Int Hlth, Baltimore, MD USA

[4] Univ Georgia, Dept Epidemiol & Stat, Athens, GA USA

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[6] ICMR, Natl Inst Virol, Pune, India

[7] ICMR, Natl JALMA Inst Leprosy & Other Mycobacterial Dis, Agra, India

[8] Natl Inst Res Reprod & Child Hlth, Mumbai, India

[9] Govt Punjab, Directorate Hlth Serv, Chandigarh, India

[10] ICMR, Reg Med Res Ctr, Dibrugarh, India

[11] Model Rural Hlth Res Unit, Dept Hlth Res, Dahanu, Maharashtra, India

[12] Model Rural Hlth Res Unit, Dept Hlth Res, Hoshiarpur, Punjab, India

[13] Model Rural Hlth Res Unit, Dept Hlth Res, Chabua, Assam, India

[14] WHO Country Off, New Delhi, India

[15] WHO Southeast Asia Reg Off, New Delhi, India

[16] PD Hinduja Hosp, Mumbai, India

[17] Med Res Ctr, Mumbai, India

[18] Tamil Nadu Housing Board, Natl Inst Epidemiol, New Delhi 600070, India

来源：

LANCET GLOBAL HEALTH | 2022年 / 10卷 / 11期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

ANTIBODIES; SEROEPIDEMIOLOGY; IMMUNITY; IMPACT; MUMPS; AGE;

D O I：

10.1016/S2214-109X(22)00379-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background India did phased measles-rubella supplementary immunisation activities (MR-SIAs; ie, mass-immunisation campaigns) targeting children aged 9 months to less than 15 years. We estimated measles-rubella seroprevalence before and after the MR-SIAs to quantify the effect on population immunity and identify remaining immunity gaps. Methods Between March 9, 2018 and March 19, 2020 we did community-based, cross-sectional serosurveys in four districts in India before and after MR-SIAs. 30 villages or wards were selected within each district, and one census enumeration block from each was selected as the survey cluster. Households were enumerated and 13 children in the younger age group (9 months to < 5 years) and 13 children in the older ager group (5 to < 15 years) were randomly selected by use of computer-generated random numbers. Serum samples were tested for IgG antibodies to measles and rubella viruses by enzyme immunoassay. Findings Specimens were collected from 2570 children before the MR-SIA and from 2619 children afterwards. The weighted MR-SIA coverage ranged from 73middot7% to 90middot5% in younger children and from 73middot6% to 93middot6% in older children. Before the MR-SIA, district-level measles seroprevalence was between 80middot7% and 88middot5% among younger children in all districts, and between 63middot4% and 84middot5% among older children. After the MR-SIA, measles seroprevalence among younger children increased to more than 90% (range 91middot5 to 96middot0) in all districts except Kanpur Nagar, in which it remained unchanged 80middot4%. Among older children, measles seroprevalence increased to more than 90middot0% (range 93middot7% to 96middot5%) in all districts except Hoshiarpur (88middot7%). A significant increase in rubella seroprevalence was observed in all districts in both age groups, with the largest effect in Dibrugarh, where rubella seroprevalence increased from 10middot6% to 96middot5% among younger children. Interpretation Measles-rubella seroprevalence increased substantially after the MR-SIAs but the serosurvey also identified remaining gaps in population immunity. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.

引用

页码：E1655 / E1664

页数：10

共 1 条

[1] Population immunity to measles virus and the effect of HIV-1 infection after a mass measles vaccination campaign in Lusaka, Zambia: a cross-sectional survey
Lowther, Sara A.
Curriero, Frank C.
Kalish, Brian T.
Shields, Timothy M.
Monze, Mwaka
Moss, William J.
LANCET, 2009, 373 (9668) : 1025 - 1032

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