Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

被引:6
作者
Wan, Teng [1 ,2 ,3 ]
Zhang, Meng [1 ,2 ,3 ]
Jiang, Hao-Ran [1 ,2 ,3 ]
Zhang, Yi-Chong [1 ,2 ,3 ]
Zhang, Xiao-Meng [1 ,2 ,3 ]
Wang, Yi-Lin [1 ,2 ,3 ]
Zhang, Pei-Xun [1 ,2 ,3 ]
机构
[1] Peking Univ Peoples Hosp, Dept Orthoped & Trauma, Beijing 100044, Peoples R China
[2] Peking Univ, Key Lab Trauma & Neural Regenerat, Beijing 100044, Peoples R China
[3] Natl Ctr Trauma Med, Beijing 100044, Peoples R China
关键词
nanomaterial; bone tissue injury; engineered bone tissue; nanoparticle; drug loading; targeted therapy; FUNCTIONALIZED GRAPHENE OXIDE; OSTEOGENIC DIFFERENTIATION; BLACK PHOSPHORUS; DRUG-DELIVERY; STEM-CELLS; NANOPARTICLES; NANOTUBES; SCAFFOLDS; NANOMEDICINE; REGENERATION;
D O I
10.3390/nano13091449
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanomaterials with bone-mimicking characteristics and easily internalized by the cell could create suitable microenvironments in which to regulate the therapeutic effects of bone regeneration. This review provides an overview of the current state-of-the-art research in developing and using nanomaterials for better bone injury repair. First, an overview of the hierarchical architecture from the macroscale to the nanoscale of natural bone is presented, as these bone tissue microstructures and compositions are the basis for constructing bone substitutes. Next, urgent clinical issues associated with bone injury that require resolution and the potential of nanomaterials to overcome them are discussed. Finally, nanomaterials are classified as inorganic or organic based on their chemical properties. Their basic characteristics and the results of related bone engineering studies are described. This review describes theoretical and technical bases for the development of innovative methods for repairing damaged bone and should inspire therapeutic strategies with potential for clinical applications.
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页数:22
相关论文
共 126 条
[91]   Studies of nanoparticle delivery with in vitro bio-engineered microtissues [J].
Sun, Mingze ;
Lee, Jinhyung ;
Chen, Yupeng ;
Hoshino, Kazunori .
BIOACTIVE MATERIALS, 2020, 5 (04) :924-937
[92]   Calcium Phosphate-Coated and Strontium-Incorporated Mesoporous Silica Nanoparticles Can Effectively Induce Osteogenic Stem Cell Differentiation [J].
Sutthavas, Pichaporn ;
Tahmasebi Birgani, Zeinab ;
Habibovic, Pamela ;
van Rijt, Sabine .
ADVANCED HEALTHCARE MATERIALS, 2022, 11 (04)
[93]   Dual-modality, fluorescent, PLGA encapsulated bismuth nanoparticles for molecular and cellular fluorescence imaging and computed tomography [J].
Swy, Eric R. ;
Schwartz-Duval, Aaron S. ;
Shuboni, Dorela D. ;
Latourette, Matthew T. ;
Mallet, Christiane L. ;
Parys, Maciej ;
Cormode, David P. ;
Shapiro, Erik M. .
NANOSCALE, 2014, 6 (21) :13104-13112
[94]   Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration [J].
Tamburaci, Sedef ;
Tihminlioglu, Funda .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2021, 128 (128)
[95]   Black phosphorus biomaterials for photo-controlled bone tissue engineering [J].
Tan, Lu ;
Li, Menghuan ;
Luo, Zhong ;
Cai, Kaiyong ;
Hu, Yan .
COMPOSITES PART B-ENGINEERING, 2022, 246
[96]   Recent Trends in the Development of Bone Regenerative Biomaterials [J].
Tang, Guoke ;
Liu, Zhiqin ;
Liu, Yi ;
Yu, Jiangming ;
Wang, Xing ;
Tan, Zhihong ;
Ye, Xiaojian .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
[97]  
Trejo I, 2019, APPL APPL MATH, V14, P687
[98]   Osteoclasts, Master Sculptors of Bone [J].
Veis, Deborah J. ;
O'Brien, Charles A. .
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2023, 18 :257-281
[99]   Plasmonic Resonance Enhanced Polarization-Sensitive Photodetection by Black Phosphorus in Near Infrared [J].
Venuthurumilli, Prabhu K. ;
Ye, Peide D. ;
Xu, Xianfan .
ACS NANO, 2018, 12 (05) :4861-4867
[100]   Nanomaterials promise better bone repair [J].
Wang, Qifei ;
Yan, Jianhua ;
Yang, Junlin ;
Li, Bingyun .
MATERIALS TODAY, 2016, 19 (08) :451-463