Exploring the role of m6A modification in cancer

被引：13

作者：

Wei, Yongqi ^{[1
]}

Li, Yin ^{[1
]}

Lu, Chunlai ^{[1
,2
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Thorac Surg, Shanghai, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Dept Thorac Surg, Shanghai 200032, Peoples R China

来源：

PROTEOMICS | 2023年 / 23卷 / 13-14期

基金：

上海市自然科学基金;

关键词：

cancer; disease mechanisms; post-translational modifications; methods; SINGLE-NUCLEOTIDE-RESOLUTION; MESSENGER-RNA STABILITY; PROMOTES GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; TRANSLATION; METTL14; PROGRESSION; SUPPRESSES; DIFFERENTIATION; DEMETHYLATION;

D O I：

10.1002/pmic.202200208

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

m6A is one of the most common, abundant, and conserved post-transcriptional modifications that regulate broad biological processes in the human body through m6A regulators. m6A regulators are figuratively classified according to their functions: writers, erasers, and readers, which can methylate RNAs, demethylate RNAs, and recognize RNA m6A sites, consequently affecting RNA fate. Tumors are an essential class of diseases that threaten human health, and as the study of m6A modification in tumors continues to advance, more and more relevant studies are emerging. In this review, we overview the recent studies of m6A in various types of tumors to demonstrate the role of m6A modification in providing a vision in diagnosing and treating tumors.

引用

页数：18

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