The molecular mechanisms of glycosaminoglycan biosynthesis regulating chondrogenesis and endochondral ossification

被引:15
作者
Chen, Yongjian [1 ]
Mehmood, Khalid [2 ]
Chang, Yung-Fu [3 ]
Tang, Zhaoxin [1 ]
Li, Ying [1 ]
Zhang, Hui [1 ]
机构
[1] South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China
[2] Islamia Univ Bahawalpur, Fac Vet & Anim Sci, Bahawalpur 63100, Pakistan
[3] Cornell Univ, Coll Vet Med, Ithaca, NY USA
基金
中国国家自然科学基金;
关键词
Chondrocytes; Glycosaminoglycan; chondrocyte; differentiation; Endochondral osteogenesis; FIBROBLAST-GROWTH-FACTOR; NUCLEUS PULPOSUS CELLS; HORMONE-RELATED PEPTIDE; OSTEOGENIC DIFFERENTIATION; OSTEOBLAST DIFFERENTIATION; CHONDROCYTE DEVELOPMENT; CARTILAGE DEVELOPMENT; SIGNALING PATHWAYS; JOINT DEVELOPMENT; BONE-FORMATION;
D O I
10.1016/j.lfs.2023.122243
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Disorders of chondrocyte differentiation and endochondral osteogenesis are major underlying factors in skeletal developmental disorders, including tibial dysplasia (TD), osteoarthritis (OA), chondrodysplasia (ACH), and multiple epiphyseal dysplasia (MED). Understanding the cellular and molecular pathogenesis of these disorders is crucial for addressing orthopedic diseases resulting from impaired glycosaminoglycan synthesis. Glycosaminoglycan is a broad term that refers to the glycan component of proteoglycan macromolecules. It is an essential component of the cartilage extracellular matrix and plays a vital role in various biological processes, including gene transcription, signal transduction, and chondrocyte differentiation. Recent studies have demonstrated that glycosaminoglycan biosynthesis plays a regulatory role in chondrocyte differentiation and endochondral osteogenesis by modulating various growth factors and signaling molecules. For instance, glycosaminoglycan is involved in mediating pathways such as Wnt, TGF-beta, FGF, Ihh-PTHrP, and O-GlcNAc glycosylation, interacting with transcription factors SOX9, BMPs, TGF-beta, and Runx2 to regulate chondrocyte differentiation and endochondral osteogenesis. To propose innovative approaches for addressing orthopedic diseases caused by impaired glycosaminoglycan biosynthesis, we conducted a comprehensive review of the molecular mechanisms underlying chondrocyte glycosaminoglycan biosynthesis, which regulates chondrocyte differentiation and endochondral osteogenesis. Our analysis considers the role of genes, glycoproteins, and associated signaling pathways during chondrogenesis and endochondral ossification.
引用
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页数:18
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