Radiation Dose Reduction for Coronary Artery Calcium Scoring Using a Virtual Noniodine Algorithm on Photon-Counting Detector Computed-Tomography Phantom Data

被引：6

作者：

Fink, Nicola ^{[1
,2
]}

Zsarnoczay, Emese ^{[1
,3
]}

Schoepf, U. Joseph ^{[1
]}

O'Doherty, Jim ^{[1
,4
]}

Griffith III, Joseph P. P. ^{[1
]}

Pinos, Daniel ^{[1
]}

Tesche, Christian ^{[1
,5
]}

Ricke, Jens ^{[2
]}

Willemink, Martin J. ^{[6
]}

Varga-Szemes, Akos ^{[1
]}

Emrich, Tilman ^{[1
,7
,8
]}

机构：

[1] Med Univ South Carolina, Dept Radiol & Radiol Sci, Div Cardiovasc Imaging, 25 Courtenay Dr, Charleston, SC 29425 USA

[2] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, Marchioninistr 15, D-81377 Munich, Germany

[3] Semmelweis Univ, Med Imaging Ctr, Koranyi Sandor Utca 2, H-1083 Budapest, Hungary

[4] Siemens Med Solut, 40 Liberty Blvd, Malvern, PA 19355 USA

[5] Ludwig Maximilians Univ Munchen, Munich Univ Clin, Dept Cardiol, Marchioninistr 15, D-81377 Munich, Germany

[6] Stanford Univ, Sch Med, Dept Radiol, 291 Campus Dr, Stanford, CA 94305 USA

[7] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Diagnost & Intervent Radiol, Langenbeckstr 1, D-55131 Mainz, Germany

[8] German Ctr Cardiovasc Res, Partner Site Rhine Main, D-55131 Mainz, Germany

来源：

DIAGNOSTICS | 2023年 / 13卷 / 09期

关键词：

coronary artery disease; photon-counting detector; computed tomography; calcium scoring; virtual noniodine; radiation dose; ITERATIVE IMAGE-RECONSTRUCTION; DUAL-SOURCE CT; CARDIOVASCULAR RISK; PROGNOSTIC VALUE; CALCIFICATION; IMPACT; QUANTIFICATION; ANGIOGRAPHY; CARDIOLOGY; GUIDELINE;

D O I：

10.3390/diagnostics13091540

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: On the basis of the hypothesis that virtual noniodine (VNI)-based coronary artery calcium scoring (CACS) is feasible at reduced radiation doses, this study assesses the impact of radiation dose reduction on the accuracy of this VNI algorithm on a photon-counting detector (PCD)-CT. Methods: In a systematic in vitro setting, a phantom for CACS simulating three chest sizes was scanned on a clinical PCD-CT. The standard radiation dose was chosen at volumetric CT dose indices (CTDIVol) of 1.5, 3.3, 7.0 mGy for small, medium-sized, and large phantoms, and was gradually reduced by adjusting the tube current resulting in 100, 75, 50, and 25%, respectively. VNI images were reconstructed at 55 keV, quantum iterative reconstruction (QIR)1, and at 60 keV/QIR4, and evaluated regarding image quality (image noise (IN), contrast-to-noise ratio (CNR)), and CACS. All VNI results were compared to true noncontrast (TNC)-based CACS at 70 keV and standard radiation dose (reference). Results: INTNC was significantly higher than INVNI, and INVNI at 55 keV/QIR1 higher than at 60 keV/QIR4 (100% dose: 16.7 +/- 1.9 vs. 12.8 +/- 1.7 vs. 7.7 +/- 0.9; p < 0.001 for every radiation dose). CNRTNC was higher than CNRVNI, but it was better to use 60 keV/QIR4 (p < 0.001). CACS(VNI) showed strong correlation and agreement at every radiation dose (p < 0.001, r > 0.9, intraclass correlation coefficient > 0.9). The coefficients of the variation in root-mean squared error were less than 10% and thus clinically nonrelevant for the CACS(VNI) of every radiation dose. Conclusion: This phantom study suggests that CACS(VNI) is feasible on PCD-CT, even at reduced radiation dose while maintaining image quality and CACS accuracy.

引用

页数：13

共 60 条

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