PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer

被引：2

作者：

Lin, Yijian ^{[1
]}

Lin, Peihuang ^{[2
]}

Guo, Weifeng ^{[1
]}

Huang, Junling ^{[1
]}

Xu, Xiaoting ^{[1
]}

Zhuang, Xibin ^{[1
,3
]}

机构：

[1] Fujian Med Univ, Dept Resp & Crit Care Med, Quanzhou Hosp 1, Quanzhou, Fujian, Peoples R China

[2] Quanzhou Med Coll, Dept Basic Med, Quanzhou, Fujian, Peoples R China

[3] Fujian Med Univ, Dept Resp & Crit Care Med, Quanzhou Hosp 1, Quanzhou 362002, Fujian, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY | 2023年 / 38卷 / 04期

关键词：

lung cancer; PLAGL2; stemness; transcriptional factor; CELLS; MIGRATION; PROLIFERATION; METASTASIS;

D O I：

10.1002/tox.23739

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study mainly focuses on revealing the role of PLAGL2 in lung cancer stemness. In vitro and in vivo experiments were performed to evaluate the effects of PLAGL2 on lung cancer cell stemness. Mechanistic analysis using luciferase reporter and ChIP assays were implemented to reveal the underlying mechanisms. The transcriptional factor E2F1 transcriptionally activated PLAGL2 expression via directly binding to PLAGL2 promoter in lung cancer cells. Moreover, PLAGL2 promoted the stemness of lung cancer cells dependent on E2F1-mediated transcriptional activation. This study provides a potential target for lung cancer progression.

引用

页码：941 / 949

页数：9

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