Onychiol B attenuates lipopolysaccharide-induced inflammation via MAPK/NF-KB pathways and acute lung injury in vivo

被引：9

作者：

Pei, Xiaoxiao ^{[1
]}

Zhang, Zeyi ^{[2
]}

Wang, Nina ^{[3
]}

Huang, Guozheng ^{[3
]}

Min, Xiaoran ^{[1
]}

Yang, Yanzi ^{[2
]}

Cao, Jianguo ^{[1
]}

机构：

[1] Shanghai Normal Univ, Coll Life Sci, Shanghai 200234, Peoples R China

[2] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China

[3] Anhui Univ Technol, Coll Chem & Chem Engn, Maanshan 243002, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2023年 / 132卷

基金：

中国国家自然科学基金;

关键词：

Onychiol B; Inflammation; ROS; Acute lung injury; CYATHANE DITERPENES; MACROPHAGES; CONSTITUENTS; ACTIVATION;

D O I：

10.1016/j.bioorg.2023.106351

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute lung injury (ALI) is a devastating respiratory disorder characterized by rapid alveolar injury, uncontrolled inflammatory response, etc. Onychiol B is a cyathane diterpene originally isolated from fern plants. In this study, onychiol B can inhibit the production and secretion of pro-inflammatory cytokines such as NO, iNOS, IL-6 and TNF-alpha in LPS-stimulated RAW264.7 cells by restraining the NF-KB and the p38 MAPK pathway. In addition, it prevents the production of ROS and reduces the loss of mitochondrial membrane potential in LPS-stimulated RAW264.7 cells. Furthermore, in the acute lung injury mouse model induced by LPS injected into the trachea, onychiol B alleviates pulmonary edema, reverses inflammatory mediator TNF-alpha, IL-6, and IL-beta secretion in lung. In general, our data show that significant anti-ALI effects of onychiol B would render it a potential candidate for the treatment of inflammatory diseases.

引用

页数：8

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