Vitrification of Mammalian Oocytes: Recent Studies on Mitochondrial Dysfunction

被引：2

作者：

Zhu, Yixiao ^{[1
]}

Liu, Hongyu ^{[1
]}

Zheng, Lv ^{[1
]}

Luo, Yuwen ^{[2
]}

Zhou, Guizhen ^{[1
]}

Li, Jun ^{[3
]}

Hou, Yunpeng ^{[2
]}

Fu, Xiangwei ^{[1
]}

机构：

[1] China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod MARA, Natl Engn Lab Anim Breeding,Beijing Key Lab Anim G, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China

[2] China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing, Peoples R China

[3] Hebei Med Univ, Hosp 1, Reprod Med Ctr, Dept Reprod Med, Shijiazhuang, Peoples R China

来源：

BIOPRESERVATION AND BIOBANKING | 2024年 / 22卷 / 05期

基金：

国家重点研发计划;

关键词：

vitrification; oocytes; mitochondria; antioxidants; GERMINAL-VESICLE STAGE; IN-VITRO MATURATION; MOUSE OOCYTES; PORCINE OOCYTES; OXIDATIVE STRESS; CYTOCHALASIN B; DEVELOPMENTAL COMPETENCE; PERMEABILITY TRANSITION; IMMATURE OOCYTES; BOVINE OOCYTES;

D O I：

10.1089/bio.2023.0062

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vitrification of reproductive cells is definitely essential and integral in animal breeding, as well as in assisted reproduction. However, issues accompanied with this technology such as decreased oocyte competency and relatively low embryo survival rates appear to be a tough conundrum that has long perplexed us. As significant organelles in cell metabolism, mitochondria play pivotal roles in numerous pathways. Nonetheless, extensive evidence has demonstrated that vitrification can seriously impair mitochondrial function in mammalian oocytes. Thus, in this article, we summarize the current progress in oocyte vitrification and particularly outline the common mitochondrial abnormalities alongside subsequent injury cascades seen in mammalian oocytes following vitrification. Based on existing literature, we tentatively come up with the potential mechanisms related to mitochondrial dysfunction and generalize efficacious ways which have been recommended to restore mitochondrial function.

引用

页码：428 / 440

页数：13

共 133 条

[111] Melatonin Improves In Vitro Development of Vitrified-Warmed Mouse Germinal Vesicle Oocytes Potentially via Modulation of Spindle Assembly Checkpoint-Related Genes [J].