Do PET-positive supradiaphragmatic lymph nodes predict overall survival or the success of primary surgery in patients with advanced ovarian cancer?

被引：0

作者：

Braun, Christian ^{[1
,3
]}

Grunig, Hannes ^{[2
]}

Peikert, Julia ^{[1
]}

Strobel, Klaus ^{[2
]}

Christmann-Schmid, Corina ^{[1
]}

Brambs, Christine ^{[1
]}

机构：

[1] Luzerner Kantonsspital, Dept Gynecol & Gynecol Oncol, Luzern, Switzerland

[2] Luzerner Kantonsspital, Dept Nucl Med, Luzern, Switzerland

[3] Luzerner Kantonsspital, Dept Gynecol & Gynecol Oncol, Spitalstr 10, CH-6000 Luzern, Switzerland

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2024年 / 296卷

关键词：

Ovarian cancer; FDG PET/CT; Supradiaphragmatic lymph nodes; Perioperative outcomes; EPITHELIAL OVARIAN; FDG PET/CT; MANAGEMENT; TOMOGRAPHY; CYTOREDUCTION; ENLARGEMENT; DIAGNOSIS; OUTCOMES;

D O I：

10.1016/j.ejogrb.2024.02.028

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives: Compared to conventional computed tomography (CT), fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) detects higher rates of lymph node and distant metastases in patients with ovarian cancer. However, FDG-PET/CT is not routinely performed during preoperative work-up. Therefore, we investigated the prognostic value of preoperative FDG-PET/CT in advanced epithelial ovarian cancer (EOC) and its predictive value for surgical resection in patients with no residual disease. The potential significance of PET-positive supradiaphragmatic lymph nodes (SDLNs) for these parameters was evaluated. Methods: All patients with FIGO IIA-IVB EOC diagnosed between March 2014 and January 2021 at our certified gynaecological cancer centre, who underwent FDG PET/CT before primary surgery were retrospectively included. Results: Fifty-three consecutive patients were included in the study. Eighteen (34 %) patients had PET-positive SDLNs. We could not demonstrate a significant correlation between PET-positive SDLNs and median overall survival (OS; SDLN-positive: 58.76 months, SDLN-negative: 60.76 months; p = 0.137) or intra- or perioperative outcomes. Conclusions: FDG PET/CT has a higher detection rate for SDLNs in patients with ovarian cancer than CT has, as described in the literature. Moreover, PET-positive SDLNs failed to predict intraoperative outcomes or overall survival.

引用

页码：13 / 19

页数：7

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