An Investigation of In Vitro Bioactivities and Cytotoxicities of Spray Pyrolyzed Apatite Wollastonite Glass-Ceramics

被引：4

作者：

Workie, Andualem Belachew ^{[1
]}

Ningsih, Henni Setia ^{[1
]}

Yeh, Wen-Ling ^{[2
,3
,4
]}

Shih, Shao-Ju ^{[1
,5
]}

机构：

[1] Natl Taiwan Univ Sci & Technol, Dept Mat Sci & Engn, 43,Sec 4 Keelung Rd, Taipei 10607, Taiwan

[2] Lotung Poh Ai Hosp, Dept Orthopead, 81 Nanchang Rd, Yilan 26546, Taiwan

[3] Chang Gung Univ, Dept Med, 259 Wenhua 1st Rd, Taoyuan 33302, Taiwan

[4] Linkou Chang Gung Mem Hosp, Dept Orthopead, 5 Fuxing Rd, Taoyuan 33373, Taiwan

[5] Kaohsiung Med Univ, Dept Fragrance & Cosmet Sci, 100 Shih Chuan 1st Rd, Kaohsiung 80708, Taiwan

来源：

CRYSTALS | 2023年 / 13卷 / 07期

关键词：

apatite-wollastonite glass ceramic; bioactivity; spray pyrolysis; biocompatibility; BEHAVIOR;

D O I：

10.3390/cryst13071049

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

An apatite-wollastonite glass ceramic (AWGC) has been recognized as one of the popular bioactive materials due to its good osteoconductivity and high mechanical properties in the field of tissue engineering. Various processes have been developed to fabricate AWGCs. Among them, the sol-gel process is one of the most popular processes. However, sol-gel has the drawbacks of discontinuous processing and long processing time, making it unsuitable for mass production. This study demonstrates a successful synthesis of AWGCs using a spray pyrolysis method to overcome these drawbacks, and the prepared pellets were sintered at temperatures of 700, 800, 900, 1000, and 1100 & DEG;C for four hours. In addition, X-ray diffraction, scanning electron microscopy, and X-ray energy-dispersive spectroscopy were used to obtain the phase composition, morphology, and chemical information of AWGCs. For bioactive measurements, among these AWGC samples, the 1100 & DEG;C sintered sample reveals the highest bioactivity. The MTT result indicates that all AWGCs are not non-toxic to the MC3T3-E1 cells and increase the growth rate of MC3T3-E1 cells.

引用

页数：12

共 29 条

[1] Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity [J].