TRP Channels in Stroke

被引：2
作者：
Zong, Pengyu [1 ,2 ]
Li, Cindy X. [1 ]
Feng, Jianlin [1 ]
Cicchetti, Mara [1 ,3 ]
Yue, Lixia [1 ]
机构：
[1] Univ Connecticut, Calhoun Cardiol Ctr, Dept Cell Biol, Sch Med,UConn Hlth, Farmington, CT 06030 USA
[2] Univ Connecticut, Connecticut Inst Brain & Cognit Sci, Unit 1272, 337 Mansfield Rd, Storrs, CT 06269 USA
[3] Univ Pittsburgh, Dept Neurosci, 4200 Fifth Ave, Pittsburgh, PA 15260 USA
来源：
NEUROSCIENCE BULLETIN | 2024年 / 40卷 / 08期
关键词：
Stroke; TRP channels; Neuronal death; Immune cell infiltration; Blood-brain barrier; Glial activation; RECEPTOR POTENTIAL CHANNELS; MELASTATIN; 2; TRPM2; CATION CHANNEL; ION-CHANNEL; OLMSTED SYNDROME; ISCHEMIC-STROKE; CA2+ CHANNEL; FUNCTIONAL-CHARACTERIZATION; NEUTROPHIL ACTIVATION; CAPSAICIN RECEPTOR;
D O I：
10.1007/s12264-023-01151-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ischemic stroke is a devastating disease that affects millions of patients worldwide. Unfortunately, there are no effective medications for mitigating brain injury after ischemic stroke. TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury. To date, many members of the TRP superfamily have been reported to contribute to ischemic brain injury, including the TRPC subfamily (1, 3, 4, 5, 6, 7), TRPV subfamily (1, 2, 3, 4) and TRPM subfamily (2, 4, 7). These TRP channels share structural similarities but have distinct channel functions and properties. Their activation during ischemic stroke can be beneficial, detrimental, or even both. In this review, we focus on discussing the interesting features of stroke-related TRP channels and summarizing the underlying cellular and molecular mechanisms responsible for their involvement in ischemic brain injury.
引用
收藏
页码：1141 / 1159
页数：19
相关论文
共 268 条
  • [1] A key role for TRPM7 channels in anoxic neuronal death
    Aarts, M
    Iihara, K
    Wei, WL
    Xiong, ZG
    Arundine, M
    Cerwinski, W
    MacDonald, JF
    Tymianski, M
    [J]. CELL, 2003, 115 (07) : 863 - 877
  • [2] Role of the chanzyme TRPM7 in the nervous system in health and disease
    Abumaria, Nashat
    Li, Wei
    Clarkson, Andrew N.
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 76 (17) : 3301 - 3310
  • [3] Poststroke Angiogenesis, Con Dark Side of Angiogenesis
    Adamczak, Joanna
    Hoehn, Mathias
    [J]. STROKE, 2015, 46 (05) : E103 - E104
  • [4] Modulation of NMDAR Subunit Expression by TRPM2 Channels Regulates Neuronal Vulnerability to Ischemic Cell Death
    Alim, Ishraq
    Teves, Lucy
    Li, Rongwen
    Mori, Yasuo
    Tymianski, Michael
    [J]. JOURNAL OF NEUROSCIENCE, 2013, 33 (44) : 17264 - 17277
  • [5] TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway
    Almasi, Shekoufeh
    Kennedy, Barry E.
    El-Aghil, Mariam
    Sterea, Andra M.
    Gujar, Shashi
    Partida-Sanchez, Santiago
    El Hiani, Yassine
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (10) : 3637 - 3650
  • [6] The biophysical and molecular basis of TRPV1 proton gating
    Aneiros, Eduardo
    Cao, Lishuang
    Papakosta, Marianthi
    Stevens, Edward B.
    Phillips, Stephen
    Grimm, Christian
    [J]. EMBO JOURNAL, 2011, 30 (06) : 994 - 1002
  • [7] Pericytes regulate the blood-brain barrier
    Armulik, Annika
    Genove, Guillem
    Mae, Maarja
    Nisancioglu, Maya H.
    Wallgard, Elisabet
    Niaudet, Colin
    He, Liqun
    Norlin, Jenny
    Lindblom, Per
    Strittmatter, Karin
    Johansson, Bengt R.
    Betsholtz, Christer
    [J]. NATURE, 2010, 468 (7323) : 557 - U231
  • [8] TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro
    Balleza-Tapia, Hugo
    Crux, Sophie
    Andrade-Talavera, Yuniesky
    Dolz-Gaiton, Pablo
    Papadia, Daniela
    Chen, Gefei
    Johansson, Jan
    Fisahn, Andre
    [J]. ELIFE, 2018, 7
  • [9] TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells
    Banik, Debarghya Dutta
    Martin, Laura E.
    Freichel, Marc
    Torregrossa, Ann-Marie
    Medler, Kathryn F.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (04) : E772 - E781
  • [10] TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection
    Beceiro, S.
    Radin, J. N.
    Chatuvedi, R.
    Piazuelo, M. B.
    Horvarth, D. J.
    Cortado, H.
    Gu, Y.
    Dixon, B.
    Gu, C.
    Lange, I.
    Koomoa, D-L T.
    Wilson, K. T.
    Algood, H. M. S.
    Partida-Sanchez, S.
    [J]. MUCOSAL IMMUNOLOGY, 2017, 10 (02) : 493 - 507
12345678910