Metal- and Solvent-Free Synthesis of Substituted Pyrimidines via an NH4I-Promoted Three-Component Tandem Reaction

被引：8

作者：

Fang, Fang ^{[1
,2
]}

Xia, Jie ^{[1
]}

Quan, Siying ^{[1
]}

Chen, Shanping ^{[1
]}

Deng, Guo-Jun ^{[1
,3
]}

机构：

[1] Xiangtan Univ, Key Lab Green Organ Synth & Applicat, Key Lab Environm Friendly Chem & Applicat, Coll Chem,Minist Educ Hunan Prov, Xiangtan 411105, Peoples R China

[2] Hunan City Univ, Coll Mat & Chem Engn, Yiyang 413000, Peoples R China

[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 20期

基金：

中国国家自然科学基金;

关键词：

N-HETERO COMPOUNDS; KETONES; DERIVATIVES; NITRILES; FORMAMIDE; CYCLOADDITION; CONSTRUCTION; CHEMISTRY; MECHANISM; ALDEHYDES;

D O I：

10.1021/acs.joc.3c01700

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and practical approach for the preparation of substituted pyrimidines from ketones, NH4OAc, and N,N-dimethylformamide dimethyl acetal has been described. This NH4I-promoted three-component tandem reaction affords a broad range of substituted pyrimidines in acceptable yields under metal- and solvent-free conditions. The present methodology features the advantages of simple and easily available starting materials, metal- and solvent-free conditions, a broad substrate scope with good functional group tolerance, and gram-scale synthesis.

引用

收藏

页码：14697 / 14707

页数：11

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