A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer

被引：0
作者：
Varne, Aarti A. [1 ]
Bhatia, Manish S. [1 ]
Ashtek, Snehal S. [1 ]
机构：
[1] Bharati Vidyapeeth Coll Pharm, Dept Pharmaceut Chem, Kolhapur 416013, Maharashtra, India
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2023年 / 57卷 / 05期
关键词：
triple-negative breast cancer; phytochemicals; chemotherapy; targets; PI3K/AKT/MTOR PATHWAY; CELL-GROWTH; MDA-MB-231; HEDGEHOG; INHIBITION; QUERCETIN; APOPTOSIS; EFFICACY; THERAPY; KINASE;
D O I：
10.1007/s11094-023-02940-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Triple-negative breast cancer (TNBC) accounts for 15 - 20% of all other types of cancer. Due to the lack of target-specific compounds against particular targets and resistance in TNBC therapy, there is a need for the development of effective therapy against TNBC. Using a natural product in chemoprevention is beneficial because of fewer side effects and low toxicity profile compared to compounds of synthetic origin. In the present review, we summarize natural products with chemopreventive activities against TNBC cell lines. In addition, we also covered targets of TNBC and conventional therapy used for treating TNBC with their mechanism of action. The present review may provide useful information on compounds for TNBC prevention.
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页码：694 / 702
页数：9
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