Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate

被引：2

作者：

Kurmaz, Svetlana, V ^{[1
]}

Ivanova, Irina I. ^{[1
]}

Emelyanova, Nina S. ^{[1
]}

Konev, Dmitry, V ^{[1
]}

Kurmaz, Vladimir A. ^{[1
]}

Filatova, Natalia, V ^{[1
]}

Balakina, Anastasia A. ^{[1
]}

Terentiev, Alexei A. ^{[1
,2
,3
]}

机构：

[1] Russian Acad Sci, Fed Res Ctr Problems Chem Phys & Med Chem, Chernogolovka 142432, Moscow Region, Russia

[2] Moscow MV Lomonosov State Univ, Dept Fundamental Phys & Chem Engn, Moscow 119991, Russia

[3] Moscow State Reg Univ, Sci & Educ Ctr, Mytishchi 141014, Moscow Region, Russia

来源：

MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 02期

关键词：

N-vinylpyrrolidone; triethylene glycol dimethacrylate; terpolymer; doxorubicin; quantum chemical modeling; cyclic voltammetry; cytotoxicity; POLYMER NANOPARTICLES; DELIVERY; COPOLYMER; CARRIERS; DESIGN;

D O I：

10.1016/j.mencom.2023.02.034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Compositions of doxorubicin with a terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate have been prepared and investigated by UV-VIS and NMR spectroscopy, cyclic voltammetry and DFT quantum chemical modeling. Oxygen containing groups of the terpolymer and hydrogen atoms of the drug OH and NH3+ groups form hydrogen bonds. The compositions have lower cytotoxicity in vitro compared with that of free doxorubicin.

引用

页码：255 / 258

页数：4

共 32 条

[1] Doxil® - The first FDA-approved nano-drug: Lessons learned
Barenholz, Yechezkel
[J]. JOURNAL OF CONTROLLED RELEASE, 2012, 160 (02) : 117 - 134
[2] Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, Elvin
Shen, Haifa
Ferrari, Mauro
[J]. NATURE BIOTECHNOLOGY, 2015, 33 (09) : 941 - 951
[3] NEW CHEMOTHERAPEUTIC AGENTS...BLEOMYCIN AND ADRIAMYCIN
CARTER, SK
BLUM, RH
[J]. CA-A CANCER JOURNAL FOR CLINICIANS, 1974, 24 (06) : 322 - 331
[4] Doxorubicin: The Good, the Bad and the Ugly Effect
Carvalho, Cristina
Santos, Renato X.
Cardoso, Susana
Correia, Sonia
Oliveira, Paulo J.
Santos, Maria S.
Moreira, Paula I.
[J]. CURRENT MEDICINAL CHEMISTRY, 2009, 16 (25) : 3267 - 3285
[5] Stimuli-responsive polymer-doxorubicin conjugate: Antitumor mechanism and potential as nano-prodrug
Chen, Kai
Cai, Hao
Zhang, Hu
Zhu, Hongyan
Gu, Zhongwei
Gong, Qiyong
Luo, Kui
[J]. ACTA BIOMATERIALIA, 2019, 84 : 339 - 355
[6] Effect of the polymer component on biocompatibility and physicochemical properties of porous zirconium ceramics
Chernyshev, Artem A.
Lytkina, Daria N.
Buiakov, Ales S.
Kulkov, Sergey N.
Kurzina, Irina A.
[J]. MENDELEEV COMMUNICATIONS, 2021, 31 (06) : 881 - 883
[7] Connors K. A., 1987, BINDING CONSTANTS ME
[8] The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction
Hoshyar, Nazanin
Gray, Samantha
Han, Hongbin
Bao, Gang
[J]. NANOMEDICINE, 2016, 11 (06) : 673 - 692
[9] Hydrogen bonds formed upon encapsulation of doxorubicin into amphiphilic N-vinylpyrrolidone copolymer: a quantum chemical study
Ignat'ev, V. M.
Emel'yanova, N. S.
Kurmaz, S. V.
Fadeeva, N. V.
[J]. RUSSIAN CHEMICAL BULLETIN, 2021, 70 (07) : 1269 - 1274
[10] Design of nanomaterials for applications in maternal/fetal medicine
Irvin-Choy, N'dea S.
Nelson, Katherine M.
Gleghorn, Jason P.
Day, Emily S.
[J]. JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (31) : 6548 - 6561

← 1 2 3 4 →