Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives

被引：51

作者：

Shi, Yan ^{[1
]}

Si, Dun ^{[1
]}

Chen, Donghong ^{[1
]}

Han, Zhigang ^{[1
]}

Yu, Qiang ^{[2
]}

Zhang, Xinfeng ^{[1
]}

Liu, Jingjing ^{[1
]}

Si, Jinping ^{[1
]}

机构：

[1] Zhejiang A&F Univ, State Key Lab Subtrop Silviculture, Hangzhou 311300, Peoples R China

[2] Nanchang Univ, State Key Lab Food Sci & Technol, China Canada Joint Lab Food Sci & Technol Nanchang, Nanchang 330047, Peoples R China

来源：

FOOD CHEMISTRY | 2023年 / 408卷

关键词：

Polygonatum genus; Diabetes; Non-starch polysaccharides; Flavonoids; Saponins; GLYCATION END-PRODUCTS; DISEASE RISK-FACTORS; STEROIDAL SAPONINS; INSULIN-RESISTANCE; ALPHA-GLUCOSIDASE; GINSENOSIDE RB1; GUT MICROBIOTA; ADIPOSE-TISSUE; SIBIRICUM POLYSACCHARIDE; HEPATIC GLUCONEOGENESIS;

D O I：

10.1016/j.foodchem.2022.135183

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Diabetes mellitus (DM) is one of the most serious health problems worldwide. Species in the genus Polygonatum are traditional food and medicinal plants, which play an important role in controlling blood glucose. In this reveiw, we systematically summarized the traditional and modern applications of the genus Polygonatum in DM, focused on the material bases of polysaccharides, flavonoids and saponins. We highlighted their mechanisms of action in preventing obese diabetes, improving insulin resistance, promoting insulin secretion, regulating in-testinal microecology, inhibiting advanced glycation end products (AGEs) accumulation, suppressing carbohy-drate digestion and obsorption and modulating gluconeogenesis. Based on the safety and efficacy of this 'medicinal food' and its utility in the prevention and treatment of diabetes, we proposed a research and development program that includs diet design (supplementary food), medical nutrition therapy and new drugs, which could provide new pathways for the use of natural plants in prevention and treatment of DM.

引用

页数：19

共 178 条

[1] Naturally Occurring Homoisoflavonoids: Phytochemistry, Biological Activities, and Synthesis (Part II) [J].

Abegaz, Berhanu M. ;

Kinfe, Henok H. .

NATURAL PRODUCT COMMUNICATIONS, 2019, 14 (05)

[2] Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats [J].

Ali, Alaa M. ;

Gabbar, Mohamed Abdel ;

Abdel-Twab, Sanaa M. ;

Fahmy, Eman M. ;

Ebaid, Hossam ;

Alhazza, Ibrahim M. ;

Ahmed, Osama M. .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020

[3] Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice [J].

Alkhalidy, Hana ;

Moore, Will ;

Wang, Aihua ;

Luo, Jing ;

McMillan, Ryan P. ;

Wang, Yao ;

Zhen, Wei ;

Hulver, Matthew W. ;

Liu, Dongmin .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2018, 58 :90-101

[4] Oleanolic acid alleviates diabetic rat carotid artery injury through the inhibition of NLRP3 inflammasome signaling pathways [J].

An, Qian ;

Hu, Qian ;

Wang, Bing ;

Cui, Wenjun ;

Wu, Fei ;

Ding, Yu .

MOLECULAR MEDICINE REPORTS, 2017, 16 (06) :8413-8419

[5]

[Anonymous], 1990, World Health Organ Tech Rep Ser, V797, P1

[6] Neratinib protects pancreatic beta cells in diabetes [J].

Ardestani, Amin ;

Li, Sijia ;

Annamalai, Karthika ;

Lupse, Blaz ;

Gerayandi, Shirin ;

Dobrowolski, Aleksandra ;

Yu, Shan ;

Zhu, Siying ;

Baguley, Tyler D. ;

Surakattula, Murali ;

Oetjen, Janina ;

Hauberg-Lotte, Lena ;

Herranz, Raquel ;

Awal, Sushil ;

Altenhofen, Delsi ;

Van Nguyen-Tran ;

Joseph, Sean ;

Schultz, Peter G. ;

Chatterjee, Arnab K. ;

Rogers, Nikki ;

Tremblay, Matthew S. ;

Shen, Weijun ;

Maedler, Kathrin .

NATURE COMMUNICATIONS, 2019, 10 (1)

[7] Liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated AKT activation [J].

Bae, Gong Deuk ;

Park, Eun-Young ;

Baek, Dong Jae ;

Jun, Hee-Sook ;

Oh, Yoon Sin .

BIOMEDICINE & PHARMACOTHERAPY, 2018, 101 :348-354

[8] Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study [J].

Barron, Emma ;

Bakhai, Chirag ;

Kar, Partha ;

Weaver, Andy ;

Bradley, Dominique ;

Ismail, Hassan ;

Knighton, Peter ;

Holman, Naomi ;

Khunti, Kamlesh ;

Sattar, Naveed ;

Wareham, Nicholas J. ;

Young, Bob ;

Valabhji, Jonathan .

LANCET DIABETES & ENDOCRINOLOGY, 2020, 8 (10) :813-822

[9] Insulin Glargine U100 Improved Glycemic Control and Reduced Nocturnal Hypoglycemia in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease Stages 3 and 4 [J].

Betonico, Carolina C. ;

Titan, Silvia Maria O. ;

Lira, Aecio ;

Pelaes, Tatiana S. ;

Correa-Giannella, Maria Lucia C. ;

Nery, Marcia ;

Queiroz, Marcia .

CLINICAL THERAPEUTICS, 2019, 41 (10) :2008-2020

[10] Pharmacological and metagenomics evidence of polysaccharide from Polygonum multiflorum in the alleviation of insulin resistance [J].

Bi, Qian ;

Gu, Wen ;

Meng, Fanying ;

Yang, Xingxin ;

Zeng, Linxi ;

Liang, Li ;

Yang, Min ;

Zhang, Ting ;

Yu, Jie .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 164 :1070-1079

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