Azvudine reduces the in-hospital mortality of COVID-19 patients: A retrospective cohort study

被引:13
作者
Zong, Kaican [1 ]
Zhou, Hui [1 ]
Li, Wen [1 ]
Jiang, E. [1 ]
Liu, Yi [2 ]
Li, Shiying [1 ,2 ]
机构
[1] Chongqing Univ Technol, Peoples Hosp Chongqing 7, Dept Resp Med, Affiliated Cent Hosp, Chongqing 400054, Peoples R China
[2] Chongqing Med Univ, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis, Dept Infect Dis,Affiliated Hosp 2,Minist Educ, Chongqing 400010, Peoples R China
关键词
Azvudine; COVID-19; Pneumonia; Mortality; MANAGEMENT;
D O I
10.1016/j.apsb.2023.07.007
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In our retrospective cohort study, we aim to explore whether Azvudine modifies the risk of death in COVID-19 patients. It was conducted on the medical records of patients, consecutively admitted for COVID-19 pneumonia to two hospitals in Chongqing, China. Based on Azvudine treatment exposure, the patients were divided into Azvudine group and non-Azvudine group. We used 1:2 ratio propensity score matching (PSM) in our study to adjust for confounding factors and differences between Azvudine and non-Azvudine groups. There were 1072 patients included in our original cohort. With 1:2 ratio PSM, the Azvudine group included 195 patients and non-Azvudine group included 390 patients. The results showed that Azvudine treatment was associated with improved in-hospital mortality in overall population (OR 0.375, 95% CI 0.225-0.62 3, P < 0.001), severe subgroup (OR 0.239, 95% CI 0.107-0.535, P = 0.001), critical subgroup (OR 0.091, 95% CI 0.011-0.769, P = 0.028) in matched cohort with uni-variate analysis. And there was a significantly lower in-hospital mortality in overall population (11% vs. 24%, P <0.001), severe sub-group (10% vs. 32%, P < 0.001) and critical sub-group (5% vs. 34%, P = 0.017) in matched cohort. These results suggest Azvudine can reduce in-hospital mortality in overall COVID-19 patients, severe, and critical subgroup population.(c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:4655 / 4660
页数:6
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