Sleep spindles as neurophysiological biomarkers of schizophrenia

Schizophrenia (SCZ) is a complex psychiatric disorder characterized by a wide range of clinical symptoms, including disrupted sleep. In recent years, there has been growing interest in assessing alterations in sleep parameters in patients with SCZ. Sleep spindles are brief (0.5-2 s) bursts of 12- to 16-Hz rhythmic electroencephalogram (EEG) oscillatory activity occurring during non-rapid eye movement (NREM) sleep. Spindles have been implicated in several critical brain functions, including learning, memory and plasticity, and are thought to reflect the integrity of underlying thalamocortical circuits. This review aims to provide an overview of the current research investigating sleep spindles in SCZ. After briefly describing the neurophysiological features of sleep spindles, I will discuss alterations in spindle characteristics observed in SCZ, their associations with the clinical symptomatology of these patients and their putative underlying neuronal and molecular mechanisms. I will then discuss the utility of sleep spindle measures as predictors of treatment response and disease progression. Finally, I will highlight future directions for research in this emerging field, including the prospect of utilizing sleep spindles as neurophysiological biomarkers of SCZ. Sleep spindles are NREM sleep oscillations that reflect the integrity of underlying thalamocortical circuits and are implicated in learning, memory and plasticity. A reduction in several spindle parameters has been reported in SCZ, including chronic, early course and at-risk individuals and has been found to be associated with the clinical symptomatology of these patients. This review reports the main spindle findings in SCZ, presents the underlying neural and molecular mechanisms and discusses the prospect of spindles as neurophysiological biomarkers of SCZ.image