Neural stem/progenitor cell-derived extracellular vesicles: A novel therapy for neurological diseases and beyond

被引：21

作者：

Li, Xiangyu ^{[1
]}

Zhu, Yingbo ^{[1
]}

Wang, Yi ^{[2
]}

Xia, Xiaohuan ^{[1
,3
,4
,5
]}

Zheng, Jialin C. ^{[1
,3
,4
,5
]}

机构：

[1] Tongji Univ Sch Med, Tongji Hosp, Ctr Translat Neurodegenerat & Regenerat Therapy, Shanghai, Peoples R China

[2] Tongji Univ, Yangzhi Rehabil Hosp, Ctr Translat Neurodegenerat & Regenerat Therapy, Shanghai, Peoples R China

[3] Tongji Univ Sch Med, Shanghai Frontiers Sci Ctr Nanocatalyt Med, Shanghai, Peoples R China

[4] Tongji Univ Sch Med, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Shanghai, Peoples R China

[5] Tongji Univ, Key Lab Spine & Spinal Cord Injury Repair & Regene, Minist Educ, Shanghai, Peoples R China

来源：

MEDCOMM | 2023年 / 4卷 / 01期

基金：

中国国家自然科学基金;

关键词：

exosomes; extracellular vesicle; neural stem; progenitor cell; neuroinflammation; neurological disease; neuroregeneration; SPINAL-CORD-INJURY; STEM-CELLS; MEDIATED ENDOCYTOSIS; PROGENITOR CELLS; MULTIPLE-SCLEROSIS; MICROGLIA DERIVE; SHEDDING LIGHT; EXOSOME UPTAKE; PHASE-I; TRANSPLANTATION;

D O I：

10.1002/mco2.214

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

As bilayer lipid membrane vesicles secreted by neural stem/progenitor cells (NSCs), NSC-derived extracellular vesicles (NSC-EVs) have attracted growing attention for their promising potential to serve as novel therapeutic agents in treatment of neurological diseases due to their unique physicochemical characteristics and biological functions. NSC-EVs exhibit advantages such as stable physical and chemical properties, low immunogenicity, and high penetration capacity to cross blood-brain barrier to avoid predicaments of the clinical applications of NSCs that include autoimmune responses, ethical/religious concerns, and the problematic logistics of acquiring fetal tissues. More importantly, NSC-EVs inherit excellent neuroprotective and neuroregenerative potential and immunomodulatory capabilities from parent cells, and display outstanding therapeutic effects on mitigating behavioral alterations and pathological phenotypes of patients or animals with neurological diseases. In this review, we first comprehensively summarize the progress in functional research and application of NSC-EVs in different neurological diseases, including neurodegenerative diseases, acute neurological diseases, dementia/cognitive dysfunction, and peripheral diseases. Next, we provide our thoughts on current limitations/concerns as well as tremendous potential of NSC-EVs in clinical applications. Last, we discuss future directions of further investigations on NSC-EVs and their probable applications in both basic and clinical research.

引用

页数：24

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