Catalyst-Free Synthesis of Polycyclic Spiroindolines by Cascade Reaction of 3-(2-Isocyanoethyl)indoles with 1-Sulfonyl-1,2,3-triazoles

被引：4
|
作者：
Chen, Cong [1 ]
Chen, Jing [1 ]
Wang, Han [1 ]
Xu, Ze-Feng [1 ]
Duan, Shengguo [1 ]
Li, Chuan-Ying [1 ]
机构：
[1] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Key Lab Surface & Interface Sci Polymer Mat Zhejia, Hangzhou 310018, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 13期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC TOTAL SYNTHESES; NATURAL-PRODUCTS; DIASTEREOSELECTIVE SYNTHESIS; ALKALOIDS; CONSTRUCTION; STRYCHNOS; FUNCTIONALIZATION; CYCLOPROPANATION; VINBLASTINE; PYRROLES;
D O I：
10.1021/acs.joc.3c00800
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalyst-free cascade reaction of 3-(2-isocyanoethyl)indolesand 1-sulfonyl-1,2,3-triazoles was realized. This dearomative spirocyclizationprovided an efficient protocol to synthesize a series of polycyclicindolines bearing spiro-alpha-carboline in moderate to high yieldsin one step under thermal reaction conditions.
引用
收藏
页码：9543 / 9553
页数：11
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