Low-dose polystyrene microplastics exposure impairs fertility in male mice with high-fat diet-induced obesity by affecting prostate function

被引：10

作者：

Gao, Dajun ^{[1
]}

Zhang, Caoxu ^{[2
]}

Guo, Huaqi ^{[3
]}

Xu, Huan ^{[1
,5
]}

Liu, Hui ^{[4
]}

Wang, Zhong ^{[1
]}

Xu, Bin ^{[1
]}

Gang, Wei ^{[6
,7
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Urol, Sch Med, Shanghai 200011, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Core Lab Med Ctr Clin Res, Dept Mol Diagnost,Sch Med,Dept Endocrinol,State Ke, Shanghai 200011, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Resp Med, Sch Med, 639 Zhizaoju Lu, Shanghai 200011, Peoples R China

[4] Bengbu Med Coll, Key Lab Canc Res, Sch Lab Med, Dept Biochem & Mol Biol, Bengbu 233030, Peoples R China

[5] Bengbu Med Coll, Sch Lab Med, Dept Biochem & Mol Biol, Clin Lab Diag, Bengbu 233030, Peoples R China

[6] Capital Med Univ, Beijing Tongren Hosp, Beijing Diabet Inst, Dept Endocrinol,Beijing Key Lab Diabet Res & Care, Beijing 100005, Peoples R China

[7] Tongji Univ, Dept Endocrinol & Metab, Shanghai Peoples Hosp 4, Sch Med, Shanghai, Peoples R China

来源：

ENVIRONMENTAL POLLUTION | 2024年 / 346卷

基金：

中国国家自然科学基金;

关键词：

Microplastics; Polystyrene; Obesity; Reproduction; Mammals; ZINC TRANSPORTERS; SPERM; INFERTILITY; DISORDERS; SYSTEM; HEALTH; AXIS;

D O I：

10.1016/j.envpol.2024.123567

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The harmful effects of microplastics (MPs) on male fertility are receiving more and more attention. However, the impact of low-dose MPs exposure on the reproductive function of male mice is still unclear. In this study, we exposed male mice to low-dose MPs (25-30 mu g/kg body weight/day) or low-dose MPs combined with high-fat diet (HFD) feeding. Our results showed that low-dose MPs exposure or HFD feeding significantly reduced sperm quality and the number of offspring born, while low-dose MPs exposure combined with HFD feeding further enhanced the above effects. The combination of low-dose MPs exposure and HFD feeding resulted in a notable elevation of inflammatory level within the prostate of mice and induced apoptosis of prostate epithelium and a decrease in nutrients (zinc, citrate) in seminal plasma fluid. Our findings in this study could provide valuable clues for better understanding the influence of low-dose MPs exposure on the reproductive system under metabolic disorders and facilitate the development of the prevention of reproductive toxicity caused by MPs exposure.

引用

页数：11

共 63 条

[1] Microplastics in the marine environment: Current trends in environmental pollution and mechanisms of toxicological profile [J].