Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention

被引：23

作者：

Qiu, Yun ^{[1
]}

Jiang, Piao ^{[2
,3
]}

Huang, Yingmei ^{[1
]}

机构：

[1] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Cardiol, Nanchang, Peoples R China

[2] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Oncol, Nanchang, Peoples R China

[3] Nanchang Univ, Clin Med Coll 1, Nanchang, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2023年 / 10卷

关键词：

anthracycline; cardiotoxicity; mechanisms; monitoring; prevention; NITRIC-OXIDE SYNTHASE; DOXORUBICIN-INDUCED CARDIOTOXICITY; VENTRICULAR SYSTOLIC DYSFUNCTION; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHILDHOOD-CANCER; INDUCED CARDIOMYOPATHY; EUROPEAN-ASSOCIATION; AMERICAN-SOCIETY; CHAMBER QUANTIFICATION; CARDIAC DYSFUNCTION;

D O I：

10.3389/fcvm.2023.1242596

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anthracyclines are the most fundamental and important treatment of several cancers especially for lymphoma and breast cancer. However, their use is limited by a dose-dependent cardiotoxicity which may emerge early at the initiation of anthracycline administration or several years after termination of the therapy. A full comprehending of the mechanisms of anthracycline-induced cardiotoxicity, which has not been achieved and is currently under the efforts, is critical to the advance of developing effective methods to protect against the cardiotoxicity, as well as to early detect and treat it. Therefore, we review the recent progress of the mechanism underlying anthracycline-induced cardiotoxicity, as well as approaches to monitor and prevent this issue.

引用

页数：15

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