Elsholblanosides A-D, Four New Oleuropeic Acid Derivatives Isolated from Elsholtzia blanda and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells

被引：6

作者：

Dung, Duong Thi ^{[1
]}

Trang, Do Thi ^{[1
]}

Yen, Pham Hai ^{[1
]}

Hoang, Nguyen Huy ^{[1
]}

Tai, Bui Huu ^{[1
,2
]}

Van Kiem, Phan ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi 10072, Vietnam

[2] Grad Univ Sci & Technol, VAST, 18 Hoang Quoc Viet, Hanoi 10072, Vietnam

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 08期

关键词：

Elsholtzia blanda; elsholblanoside A; elsholblanoside B; elsholblanoside C; elsholblanoside D; PHENYLVALERIC ACID; GLYCOSIDES;

D O I：

10.1002/cbdv.202300785

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation on the aerial parts of Elsholtzia blanda Benth. afforded four new oleuropeic acid derivatives (1-4), named as elsholblanosides A-D, respectively, together with 11 known compounds (5-15). Their structures were determined based on extensive analyses of HR-ESI-MS, 1D and 2D NMR, and ECD spectra. Compounds 1-4 and 14 showed moderate NO production inhibition in LPS-activated RAW264.7 cells with their IC50 values ranging from 23.2 to 86.33 & mu;M, compared to that of the positive control compound, dexamethasone, IC50 value of 16.9 & mu;M.

引用

页数：6

共 26 条

[1]

Abe F, 1999, CHEM PHARM BULL, V47, P869

[2]

Bestmann H. J., 1992, Journal of Essential Oil Research, V4, P121

[3]

Bich D.H., 2004, PUBLISHING SCI TECHN, V2, P122

[4] MEDICINAL-PLANTS OF SOUTHERN-AFRICA .3. A GERANIOL GLYCOSIDE FROM HYPOXIS-ACUMINATA [J].

BREDENKAMP, MW ;

DREWES, SE ;

WENTLER, GL .

PHYTOCHEMISTRY, 1989, 28 (01) :263-265

[5] Phenylvaleric acid and flavonoid glycosides from Polygonum salicifolium [J].

Calis, I ;

Kuruüzüm, A ;

Demirezer, LÖ ;

Sticher, O ;

Ganci, W ;

Rüedi, P .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (08) :1101-1105

[6] Inhibition of Nitric Oxide (NO) Production in Lipopolysaccharide (LPS)-Activated Murine Macrophage RAW 264.7 Cells by the Norsesterterpene Peroxide, Epimuqubilin A [J].

Cheenpracha, Sarot ;

Park, Eun-Jung ;

Rostama, Bahman ;

Pezzuto, John M. ;

Chang, Leng Chee .

MARINE DRUGS, 2010, 8 (03) :429-437

[7]

Chen Hai-yong, 2005, Zhongguo Zhong Yao Za Zhi, V30, P1589

[8] Two jasmonoid glucosides and a phenylvaleric acid glucoside from Perilla frutescens [J].

Fujita, T ;

Terato, K ;

Nakayama, M .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1996, 60 (04) :732-735

[9]

Ganci WM, 2000, CHIRALITY, V12, P139, DOI 10.1002/(SICI)1520-636X(2000)12:3<139::AID-CHIR6>3.0.CO

[10]

2-3

← 1 2 3 →