Eco-Friendly synthesis of manganese nanoparticles from Syzygium aromaticum and study of their biological activities

Different metallic nanoparticles are being explored, but manganese nanoparticles (MnNPs) have not yet been studied extensively. In this study, MnNPs were synthesized by a plant-based (clove extract) method, and the synthesized MnNPs were physically characterized using different techniques. SEM analysis showed a size range of MnNPs between 100 nm and 500 nm with spherical shapes. XRD analysis showed the crystalline nature of MnNPs. The PDI of 0.872 and the zeta potential at 10 mV indicate that the MnNPs are aggregated and polydispersed. MnNPs showed a maximum zone of inhibition against Staphylococcus aureus, i.e. 30 mm. The DPPH assay confirmed the radical scavenging ability of nanoparticles with an IC50 of 51.18 mu g/ml. The alpha-amylase and alpha-glucosidase assays indicated that green synthesized MnNPs can act as an anti-diabetic agent with 26.65 mu g/ml and 27.37 mu g/ml IC50 values, respectively. In conclusion, this work exhibited a cost-effective and non-toxic method of MnNPs synthesis with potential biomedical applications.