Photocatalytic decarboxylative phosphorylation of N-aryl glycines

被引：10

作者：

Wen, Jiangwei ^{[1
]}

Sun, Xue ^{[1
]}

Yan, Kelu ^{[1
]}

Yan, Tingtao ^{[1
]}

Liu, Zhen ^{[1
]}

Li, Yang ^{[1
]}

Yang, Jianjing ^{[1
]}

机构：

[1] Qufu Normal Univ, Key Lab Green Nat Prod & Pharmaceut Intermediates, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

ALPHA-AMINO-ACIDS; PHOSPHORUS-ACID; DERIVATIVES; PHOTOREDOX; INHIBITORS; CHEMISTRY; ROUTE;

D O I：

10.1039/d3qo01577g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct decarboxylative phosphorylation of N-aryl glycines is an appealing method for the synthesis of alpha-amino phosphine oxides. In this study, we present the first instance of a straightforward and practical approach for achieving decarboxylative phosphorylation of N-aryl glycines to obtain alpha-amino phosphine oxides under visible-light photoredox catalysis. This simple visible light catalytic protocol demonstrated smooth efficiency and excellent tolerance towards functional groups. Furthermore, it can be easily scaled up to the gram scale using extremely mild conditions, all while avoiding the use of a metal and base.

引用

收藏

页码：796 / 801

页数：6

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