Longevity through diet restriction and immunity

被引：5

作者：

Hahm, Jeong-Hoon ^{[1
]}

Seo, Hyo-Deok ^{[1
]}

Jung, Chang Hwa ^{[1
,2
]}

Ahn, Jiyun ^{[1
,2
]}

机构：

[1] Korea Food Res Inst, Aging & Metab Res Grp, Wonju 55365, South Korea

[2] Univ Sci & Technol, Dept Food Biotechnol, Daejeon 34113, South Korea

来源：

BMB REPORTS | 2023年 / 56卷 / 10期

关键词：

Aging; Diet restriction; Disease; Immunity; Longevity; TERM CALORIE RESTRICTION; LIFE-SPAN EXTENSION; CAENORHABDITIS-ELEGANS; TOR PATHWAY; C; ELEGANS; LONG; GROWTH; HEALTH; IGF-1; REGENERATION;

D O I：

10.5483/BMBRep.2023-0095

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DRinduced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human. [BMB Reports 2023; 56(10): 537-544]

引用

页码：537 / 544

页数：8

共 89 条

[1] Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice [J].

Acosta-Rodriguez, Victoria ;

Rijo-Ferreira, Filipa ;

Izumo, Mariko ;

Xu, Pin ;

Wight-Carter, Mary ;

Green, Carla B. ;

Takahashi, Joseph S. .

SCIENCE, 2022, 376 (6598) :1192-+

[2] Longevity in Untreated Congenital Growth Hormone Deficiency Due to a Homozygous Mutation in the GHRH Receptor Gene [J].

Aguiar-Oliveira, Manuel H. ;

Oliveira, Francielle T. ;

Pereira, Rossana M. C. ;

Oliveira, Carla R. P. ;

Blackford, Amanda ;

Valenca, Eugenia H. O. ;

Santos, Elenilde G. ;

Gois-Junior, Miburge B. ;

Meneguz-Moreno, Rafael A. ;

Araujo, Vanessa P. ;

Oliveira-Neto, Luis A. ;

Almeida, Roque P. ;

Santos, Mario A. ;

Farias, Natalia T. ;

Silveira, Debora C. R. ;

Cabral, Gabriel W. ;

Calazans, Flavia R. ;

Seabra, Juliane D. ;

Lopes, Tiago F. ;

Rodrigues, Endrigo O. ;

Porto, Livia A. ;

Oliveira, Igor P. ;

Melo, Enaldo V. ;

Martari, Marco ;

Salvatori, Roberto .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (02) :714-721

[3] Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention [J].

Aiello, Anna ;

Farzaneh, Farzin ;

Candore, Giuseppina ;

Caruso, Calogero ;

Davinelli, Sergio ;

Gambino, Caterina Maria ;

Ligotti, Mattia Emanuela ;

Zareian, Nahid ;

Accardi, Giulia .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[4] Metformin slows down aging and extends life span of female SHR mice [J].

Anisimov, Vladimir N. ;

Berstein, Lev M. ;

Egormin, Peter A. ;

Piskunova, Tatiana S. ;

Popovich, Irina G. ;

Zabezhinski, Mark A. ;

Tyndyk, Margarita L. ;

Yurova, Maria V. ;

Kovalenko, Irina G. ;

Poroshina, Tatiana E. ;

Semenchenko, Anna V. .

CELL CYCLE, 2008, 7 (17) :2769-2773

[5] Does Reduced IGF-1R Signaling in Igf1r+/- Mice Alter Aging? [J].

Bokov, Alex F. ;

Garg, Neha ;

Ikeno, Yuji ;

Thakur, Sachin ;

Musi, Nicolas ;

DeFronzo, Ralph A. ;

Zhang, Ning ;

Erickson, Rebecca C. ;

Gelfond, Jon ;

Hubbard, Gene B. ;

Adamo, Martin L. ;

Richardson, Arlan .

PLOS ONE, 2011, 6 (11)

[6] A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan [J].

Brandhorst, Sebastian ;

Choi, In Young ;

Wei, Min ;

Cheng, Chia Wei ;

Sedrakyan, Sargis ;

Navarrete, Gerardo ;

Dubeau, Louis ;

Yap, Li Peng ;

Park, Ryan ;

Vinciguerra, Manlio ;

Di Biase, Stefano ;

Mirzaei, Hamed ;

Mirisola, Mario G. ;

Childress, Patra ;

Ji, Lingyun ;

Groshen, Susan ;

Penna, Fabio ;

Odetti, Patrizio ;

Perin, Laura ;

Conti, Peter S. ;

Ikeno, Yuji ;

Kennedy, Brian K. ;

Cohen, Pinchas ;

Morgan, Todd E. ;

Dorff, Tanya B. ;

Longo, Valter D. .

CELL METABOLISM, 2015, 22 (01) :86-99

[7] InnateDB: systems biology of innate immunity and beyond-recent updates and continuing curation [J].

Breuer, Karin ;

Foroushani, Amir K. ;

Laird, Matthew R. ;

Chen, Carol ;

Sribnaia, Anastasia ;

Lo, Raymond ;

Winsor, Geoffrey L. ;

Hancock, Robert E. W. ;

Brinkman, Fiona S. L. ;

Lynn, David J. .

NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D1228-D1233

[8] Insect Innate Immunity Database (IIID): An Annotation Tool for Identifying Immune Genes in Insect Genomes [J].

Brucker, Robert M. ;

Funkhouser, Lisa J. ;

Setia, Shefali ;

Pauly, Rini ;

Bordenstein, Seth R. .

PLOS ONE, 2012, 7 (09)

[9] HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans [J].

Chen, Di ;

Thomas, Emma Lynn ;

Kapahi, Pankaj .

PLOS GENETICS, 2009, 5 (05)

[10] Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression [J].

Cheng, Chia-Wei ;

Adams, Gregor B. ;

Perin, Laura ;

Wei, Min ;

Zhou, Xiaoying ;

Lam, Ben S. ;

Da Sacco, Stefano ;

Mirisola, Mario ;

Quinn, David I. ;

Dorff, Tanya B. ;

Kopchick, John J. ;

Longo, Valter D. .

CELL STEM CELL, 2014, 14 (06) :810-823

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