Learning-prolonged maintenance of stimulus information in CA1 and subiculum during trace fear conditioning

被引:5
作者
Bai, Tao [1 ,2 ]
Zhan, Lijie [1 ]
Zhang, Na [1 ]
Lin, Feikai [1 ]
Saur, Dieter
Xu, Chun [1 ,2 ,3 ,4 ]
机构
[1] Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Tech Univ Munich, Dept Internal Med 2, Ismaningerstr 22, D-81675 Munich, Germany
[4] Shanghai Ctr Brain Sci & Brain Inspired Technol, Shanghai 201210, Peoples R China
来源
CELL REPORTS | 2023年 / 42卷 / 08期
基金
中国国家自然科学基金;
关键词
DORSAL HIPPOCAMPUS; NEURONAL CIRCUITS; NEURAL CIRCUITS; NMDA RECEPTORS; MEMORY; TIME; INVOLVEMENT; PLASTICITY; CELLS; NEUROBIOLOGY;
D O I
10.1016/j.celrep.2023.112853
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Temporal associative learning binds discontiguous conditional stimuli (CSs) and unconditional stimuli (USs), possibly by maintaining CS information in the hippocampus after its offset. Yet, how learning regulates such maintenance of CS information in hippocampal circuits remains largely unclear. Using the auditory trace fear conditioning (TFC) paradigm, we identify a projection from the CA1 to the subiculum critical for TFC. Deep -brain calcium imaging shows that the peak of trace activity in the CA1 and subiculum is extended toward the US and that the CS representation during the trace period is enhanced during learning. Interestingly, such plasticity is consolidated only in the CA1, not the subiculum, after training. Moreover, CA1 neurons, but not subiculum neurons, increasingly become active during CS-and-trace and shock periods, respectively, and correlate with CS-evoked fear retrieval afterward. These results indicate that learning dynamically en-hances stimulus information maintenance in the CA1-subiculum circuit during learning while storing CS and US memories primarily in the CA1 area.
引用
收藏
页数:20
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