Metal phenolic networks (MPNs)-based pH-sensitive stimulus responsive nanosystems for drug delivery in tumor microenvironment

被引：21

作者：

Ali, Arbab ^{[1
,2
]}

Javed, Rabia ^{[3
]}

Farhangi, Sahar ^{[4
]}

Shah, Tufail ^{[5
]}

Ullah, Sana ^{[6
,7
]}

ul Ain, Noor ^{[6
]}

Liu, Tao ^{[2
]}

Lynch, Iseult ^{[8
]}

Raza, Faisal ^{[9
]}

Zhang, Peng ^{[10
]}

Rui, YuKui ^{[1
]}

机构：

[1] China Agr Univ, Coll Resources & Environm Sci, Beijing Key Lab Farmland Soil Pollut Prevent & Rem, Beijing 100193, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nano Safety, Beijing 100190, Peoples R China

[3] China Med Univ, Dept Tissue Engn, Shenyang 110122, Peoples R China

[4] Tarbiat Modares Univ, Fac Med Sci, Dept Physiol, Tehran, Iran

[5] China Agr Univ, Coll Land Sci & Technol, Beijing 100193, Peoples R China

[6] Quaid i Azam Univ, Dept Biotechnol, Islamabad 45320, Pakistan

[7] Univ Nizzwa, Nat & Med Sci Res Ctr, Nizwa, Oman

[8] Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham, W Midlands, England

[9] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[10] Univ Sci & Technol China, Dept Environm Sci & Engn, Hefei 230026, Peoples R China

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 84卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Tumor microenvironment (TME); Metal phenolic networks (MPNs); pH; -sensitive; Drug delivery; Cancer therapy; SOLID LIPID NANOPARTICLES; IRON-OXIDE NANOPARTICLES; NA+/H+ EXCHANGER NHE1; EXTRACELLULAR PH; GOLD NANOPARTICLES; VERSATILE PLATFORM; INTERSTITIAL PH; MELANOMA-CELLS; ACIDIC PH; CANCER;

D O I：

10.1016/j.jddst.2023.104536

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The tumor microenvironment (TME) is a dynamic and complex system characterized by different cellular, mo-lecular, and physiological heterogeneity. Therefore, conventional drug delivery strategies often failed to deliver an effective dosage to kill cancerous cells. In recent years, the development of nano-based drug delivery has expanded into a wide range of clinical applications to address the limitations of free therapeutics and voyage the biological barriers. Recently, stimuli-responsive metal phenolic networks (MPNs) have recently become a focus of intense scientific investigation in biomedical applications, and offer a versatile platform for controlled release of therapeutics in TME. This review provides a timely and thorough description of the use of a MPNs in the rapidly evolving field of advanced drug delivery with insights unique to pH-stimulus responsive systems. This review aims to offer an in-depth understanding of the potential use of MPNs as pH-sensitive therapeutics carriers in TME. We briefly explained the endogenous pH-associated factors affecting the therapeutics delivery in TME. A cross comparison of the advantages and disadvantages of MPNs with other counterparts are highlighted to elucidate their key design principles for pH-stimulus responsive drug delivery in TME. In later sections, pros and cons of MPNs as well as current challenges and future perspectives are also discussed, which will deepen our understanding of designing, fabricating, and applying MPNs for advanced therapeutics.

引用

页数：15

共 184 条

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