Adverse effects of microcystins on sperm: A systematic review

被引：6

作者：

Zhang, Zongxin ^{[1
]}

Du, Xingde ^{[1
]}

Zhang, Shiyu ^{[1
]}

Liu, Haohao ^{[1
]}

Fu, Yu ^{[1
]}

Wang, Fufang ^{[1
]}

Zhang, Huizhen ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Peoples R China

来源：

TOXICOLOGY | 2023年 / 490卷

基金：

中国国家自然科学基金;

关键词：

Handling Editor; Dr; Mathieu Vinken; MCs; Sperm; Spermatogenesis; Toxicity; Hormone; Blood -testis barrier; INDUCED REPRODUCTIVE TOXICITY; BLOOD-TESTIS BARRIER; FRESH-WATER; OXIDATIVE STRESS; CHINESE LAKE; LR; RAT; ROLES; EXPRESSION; EXPOSURE;

D O I：

10.1016/j.tox.2023.153507

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eutrophication of water bodies can lead to cyanobacterial blooms, with the resultant release of microcystins (MCs), posing a threat to the ecosystem and human health. MCs are environmental toxins with male reproductive toxicity. However, there is a dearth of reviews focusing on sperm or spermatogenesis. In this paper, studies on sperm toxicity caused by MCs in recent 20 years were collected and summarized, aiming at revealing the toxic effects and potential mechanisms of MCs on sperm. Based on the previous findings, MCs can decline sperm quality and count, and cause malformation in vertebrates and invertebrates. The reason might be that MCs cause indirect damage to sperm through impairing the structure and function of the testis. The mechanisms of MCsinduced sperm toxicity mainly result from alterations in genetic material, abnormalities in the structure and function of sperm. The epigenetic modifications such as miRNA and piRNA were also involved in MC-LR-induced sperm damage. In conclusion, MCs exposure is harmful to sperm, but its direct effects and mechanisms on sperm are still not known, which remains a significant research direction. Our review will provide a basis for the protection of male reproductive health damage caused by microcystins.

引用

页数：9

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