Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

被引：55

作者：

Panda, Siva S. S. ^{[1
]}

Girgis, Adel S. S. ^{[2
]}

Aziz, Marian N. N. ^{[2
]}

Bekheit, Mohamed S. S. ^{[2
]}

机构：

[1] Augusta Univ, Dept Chem & Phys, Augusta, GA 30912 USA

[2] Natl Res Ctr, Dept Pesticide Chem, Giza 12622, Egypt

来源：

MOLECULES | 2023年 / 28卷 / 02期

关键词：

spirooxindole; synthesis; natural product; alkaloids; biological properties; ONE-POT SYNTHESIS; SPIRO; DERIVATIVES; ARTEMISININ; INHIBITORS; ALKALOIDS; DISCOVERY; OXINDOLES; HYBRIDS; DESIGN;

D O I：

10.3390/molecules28020618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.

引用

页数：32

共 50 条

[31] The Solubility Studies and the Complexation Mechanism Investigations of Biologically Active Spiro[cyclopropane-1,3′-oxindoles] with β-Cyclodextrins
Kravtsova, Anna A.
Skuredina, Anna A.
Malyshev, Alexander S.
Le-Deygen, Irina M.
Kudryashova, Elena V.
Budynina, Ekaterina M.
[J]. PHARMACEUTICS, 2023, 15 (01)
[32] Diversely functionalized isoquinolines and their core-embedded heterocyclic frameworks: a privileged scaffold for medicinal chemistry
Vijayakumar, Archana
Manod, M.
Krishna, R. Bharath
Mathew, Abra
Mohan, Chithra
[J]. RSC MEDICINAL CHEMISTRY, 2023, 14 (12): : 2509 - 2534
[33] A Review of Biologically Active Oxime Ethers
Kosmalski, Tomasz
Kupczyk, Daria
Baumgart, Szymon
Paprocka, Renata
Studzinska, Renata
[J]. MOLECULES, 2023, 28 (13):
[34] Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma
Barakat, Assem
Alshahrani, Saeed
Al-Majid, Abdullah Mohammed
Alamary, Abdullah Saleh
Haukka, Matti
Abu-Serie, Marwa M.
Domling, Alexander
Mazyed, Eman A.
Badria, Farid A.
El-Senduny, Fardous F.
[J]. BIOORGANIC CHEMISTRY, 2022, 129
[35] Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors
Jayan, Jayalakshmi
Chandran, Namitha
Thekkantavida, Amrutha Chandran
Abdelgawad, Mohamed A.
Ghoneim, Mohammed M.
Shaker, Mohamed E.
Uniyal, Prerna
Benny, Feba
Zachariah, Subin Mary
Kumar, Sunil
Kim, Hoon
Mathew, Bijo
[J]. ACS OMEGA, 2023, 8 (41): : 37731 - 37751
[36] Facile Synthesis and Antimicrobial Evaluation of Some New Heterocyclic Compounds Incorporating a Biologically Active Sulfamoyl Moiety
Darwish, Elham S.
[J]. SCIENTIFIC WORLD JOURNAL, 2014,
[37] Catalyst-free four-component domino synthetic approach toward versatile multicyclic spirooxindole pyran scaffolds
Mohammadi, Aref
Bayat, Mohammad
Nasri, Shima
[J]. RSC ADVANCES, 2019, 9 (29) : 16525 - 16533
[38] CHEMICAL AND BIOLOGICALLY ACTIVE CONSTITUENTS OF Salsola collina
Jin, Yong-Sheng
Du, Jing-Ling
Yang, Yan
Jin, Li
Song, Yan
Zhang, Wei
Chen, Hai-Sheng
[J]. CHEMISTRY OF NATURAL COMPOUNDS, 2011, 47 (02) : 257 - 260
[39] Anticancer Activity of Novel Benzo[d] [1,3] dioxol Carrying a Biologically Active Heterocyclic Moieties
Ghorab, Mostafa M.
Alsaid, Mansour S.
[J]. LATIN AMERICAN JOURNAL OF PHARMACY, 2015, 34 (10): : 1984 - 1994
[40] [3+2] Cycloaddition Reaction for the Stereoselective Synthesis of a New Spirooxindole Compound Grafted Imidazo[2,1-b]thiazole Scaffold: Crystal Structure and Computational Study
Altowyan, Mezna Saleh
Soliman, Saied M.
Haukka, Matti
Al-Shaalan, Nora Hamad
Alkharboush, Aminah A.
Barakat, Assem
[J]. CRYSTALS, 2022, 12 (01)

← 1 2 3 4 5 →