Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

被引：70

作者：

Panda, Siva S. S. ^{[1
]}

Girgis, Adel S. S. ^{[2
]}

Aziz, Marian N. N. ^{[2
]}

Bekheit, Mohamed S. S. ^{[2
]}

机构：

[1] Augusta Univ, Dept Chem & Phys, Augusta, GA 30912 USA

[2] Natl Res Ctr, Dept Pesticide Chem, Giza 12622, Egypt

来源：

MOLECULES | 2023年 / 28卷 / 02期

关键词：

spirooxindole; synthesis; natural product; alkaloids; biological properties; ONE-POT SYNTHESIS; SPIRO; DERIVATIVES; ARTEMISININ; INHIBITORS; ALKALOIDS; DISCOVERY; OXINDOLES; HYBRIDS; DESIGN;

D O I：

10.3390/molecules28020618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.

引用

页数：32

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