Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis

被引：20

作者：

Liu, Peng ^{[1
]}

Qian, Yerong ^{[1
,2
]}

Liu, Xin ^{[3
]}

Zhu, Xulong ^{[4
]}

Zhang, Xufeng ^{[2
]}

Lv, Yi ^{[1
,2
]}

Xiang, Junxi ^{[2
]}

机构：

[1] Xi An Jiao Tong Univ, Med X Inst, Ctr Regenerat & Reconstruct Med, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China

[3] Xian Med Univ, Dept Radiotherapy, Xian, Shaanxi, Peoples R China

[4] Shaanxi Prov Peoples Hosp, Dept Surg Oncol, Xian, Shaanxi, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 13卷

基金：

中国国家自然科学基金;

关键词：

liver fibrosis; mesenchymal stem cell; immunomodulatory effects; exosome; antifibrosis; TRANSPLANTATION; GENERATION; AUTOPHAGY; INJURY;

D O I：

10.3389/fimmu.2022.1096402

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Liver fibrosis is a fibrogenic and inflammatory process that results from hepatocyte injury and is characterized by hepatic architectural distortion and resultant loss of liver function. There is no effective treatment for advanced fibrosis other than liver transplantation, but it is limited by expensive costs, immune rejection, and postoperative complications. With the development of regenerative medicine in recent years, mesenchymal stem cell (MSCs) transplantation has become the most promising treatment for liver fibrosis. The underlying mechanisms of MSC anti-fibrotic effects include hepatocyte differentiation, paracrine, and immunomodulation, with immunomodulation playing a central role. This review discusses the immune cells involved in liver fibrosis, the immunomodulatory properties of MSCs, and the immunomodulation mechanisms of MSC-based strategies to attenuate liver fibrosis. Meanwhile, we discuss the current challenges and future directions as well.

引用

页数：10

共 99 条

[1] Mesenchymal stromal cell therapy for liver diseases [J].

Alfaifi, Mohammed ;

Eom, Young Woo ;

Newsome, Philip N. ;

Baik, Soon Koo .

JOURNAL OF HEPATOLOGY, 2018, 68 (06) :1272-1285

[2] Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: Results of the ELITA/EF-CLIF collaborative study (ECLIS) [J].

Belli, Luca S. ;

Duvoux, Christophe ;

Artzner, Thierry ;

Bernal, William ;

Conti, Sara ;

Cortesi, Paolo A. ;

Sacleux, Sophie-Caroline ;

Pageaux, George-Philippe ;

Radenne, Sylvie ;

Trebicka, Jonel ;

Fernandez, Javier ;

Perricone, Giovanni ;

Piano, Salvatore ;

Nadalin, Silvio ;

Morelli, Maria C. ;

Martini, Silvia ;

Polak, Wojciech G. ;

Zieniewicz, Krzysztof ;

Toso, Christian ;

Berenguer, Marina ;

Iegri, Claudia ;

Invernizzi, Federica ;

Volpes, Riccardo ;

Karam, Vincent ;

Adam, Rene ;

Faitot, Francois ;

Rabinovich, Liane ;

Saliba, Faouzi ;

Meunier, Lucy ;

Lesurtel, Mickael ;

Uschner, Frank E. ;

Fondevila, Costantino ;

Michard, Baptiste ;

Coilly, Audrey ;

Meszaros, Magdalena ;

Poinsot, Domitille ;

Schnitzbauer, Andreas ;

De Carlis, Luciano G. ;

Fumagalli, Roberto ;

Angeli, Paolo ;

Arroyo, Vincente ;

Jalan, Rajiv .

JOURNAL OF HEPATOLOGY, 2021, 75 (03) :610-622

[3] Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia [J].

Boumaza, Imene ;

Srinivasan, Suganya ;

Witt, William T. ;

Feghali-Bostwick, Carol ;

Dai, Yifan ;

Garcia-Ocana, Adolfo ;

Feili-Hariri, Maryam .

JOURNAL OF AUTOIMMUNITY, 2009, 32 (01) :33-42

[4] Mesenchymal stem cell therapy for liver fibrosis/cirrhosis [J].

Cao, Yan ;

Ji, Chenbo ;

Lu, Ling .

ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (08)

[5] RETRACTED: Overexpression of TGFβ1 in murine mesenchymal stem cells improves lung inflammation by impacting the Th17/Treg balance in LPS-induced ARDS mice (Retracted article. See vol. 13, 2022) [J].

Chen, Jianxiao ;

Zhang, Xiwen ;

Xie, Jianfeng ;

Xue, Ming ;

Liu, Ling ;

Yang, Yi ;

Qiu, Haibo .

STEM CELL RESEARCH & THERAPY, 2020, 11 (01)

[6] Therapeutic effects of serum extracellular vesicles in liver fibrosis [J].

Chen, Li ;

Chen, Ruju ;

Kemper, Sherri ;

Cong, Min ;

You, Hong ;

Brigstock, David R. .

JOURNAL OF EXTRACELLULAR VESICLES, 2018, 7 (01)

[7] The immune niche of the liver [J].

Cheng, Michael L. ;

Nakib, Diana ;

Perciani, Catia T. ;

MacParland, Sonya A. .

CLINICAL SCIENCE, 2021, 135 (20) :2445-2466

[8] Efficacy of stem cell-based therapies for stroke [J].

Chrostek, Matthew R. ;

Fellows, Emily G. ;

Crane, Andrew T. ;

Grande, Andrew W. ;

Low, Walter C. .

BRAIN RESEARCH, 2019, 1722

[9] Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke [J].

Chung, Jong-Won ;

Chang, Won Hyuk ;

Bang, Oh Young ;

Moon, Gyeong Joon ;

Kim, Suk Jae ;

Kim, Soo-Kyoung ;

Lee, Jin Soo ;

Sohn, Sung-Il ;

Kim, Yun-Hee .

NEUROLOGY, 2021, 96 (07) :E1012-E1023

[10] Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis [J].

Coll, Mar ;

Perea, Luis ;

Boon, Ruben ;

Leite, Sofia B. ;

Vallverdu, Julia ;

Mannaerts, Inge ;

Smout, Ayla ;

El Taghdouini, Adil ;

Blaya, Delia ;

Rodrigo-Torres, Daniel ;

Graupera, Isabel ;

Aguilar-Bravo, Beatriz ;

Chesne, Christophe ;

Najimi, Mustapha ;

Sokal, Etienne ;

Jose Lozano, Juan ;

van Grunsven, Leo A. ;

Verfaillie, Catherine M. ;

Sancho-Bru, Pau .

CELL STEM CELL, 2018, 23 (01) :101-+

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