Senopathies-Diseases Associated with Cellular Senescence

被引:12
作者
Lushchak, Oleh [1 ,2 ,3 ]
Schosserer, Markus [4 ,5 ]
Grillari, Johannes [1 ,5 ,6 ]
机构
[1] Ludwig Boltzmann Inst Traumatol, Res Ctr Cooperat AUVA, A-1200 Vienna, Austria
[2] Precarpathian Natl Univ, Dept Biochem & Biotechnol, UA-76000 Ivano Frankivsk, Ukraine
[3] Res & Dev Univ, UA-76018 Ivano Frankivsk, Ukraine
[4] Med Univ Vienna, Inst Med Genet, Ctr Pathobiochem & Genet, A-1090 Vienna, Austria
[5] Austrian Cluster Tissue Regenerat, A-1200 Vienna, Austria
[6] Univ Nat Resources & Life Sci, Inst Mol Biotechnol, Dept Biotechnol, A-1190 Vienna, Austria
基金
奥地利科学基金会;
关键词
cellular senescence; aging; senopathy; senolytic; senomorphic; senotherapy; geroscience; senescence-associated secretory phenotype (SASP); pathology; age-related disease; SECRETORY PHENOTYPE; CELLS; FIBROSIS; MECHANISMS; CLEARANCE; METFORMIN; SHORTEN; CANCER; SASP;
D O I
10.3390/biom13060966
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies. We propose to refer to all diseases whose pathogenesis or progression is associated with cellular senescence as "senopathies". Targeting senescent cells with senolytics or senomorphics is likely to mitigate these pathologies. Examples of senopathies include cardiovascular, metabolic, musculoskeletal, liver, kidney, and lung diseases and neurodegeneration. For all these pathologies, animal studies provide clear mechanistic evidence for a connection between senescent cell accumulation and disease progression. The major persisting challenge in developing novel senotherapies is the heterogeneity of senescence phenotypes, causing a lack of universal biomarkers and difficulties in discriminating senescent from non-senescent cells.
引用
收藏
页数:10
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