MST1: A future novel target for cardiac diseases

被引：10
|
作者：
Shao, Yingchun [1 ]
Wang, Yanhong [1 ]
Sun, Li [1 ]
Zhou, Sha [1 ]
Xu, Jiazhen [1 ]
Xing, Dongming [1 ,2 ,3 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Qingdao Canc Inst, Canc Inst, Qingdao 266071, Peoples R China
[2] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
[3] Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 239卷
关键词：
Mammalian sterile 20-like kinase 1; Cardiomyocyte; Apoptosis; Cardiac diseases; ISCHEMIA-REPERFUSION INJURY; UP-REGULATING AUTOPHAGY; OXIDATIVE-STRESS; INDUCED CARDIOTOXICITY; HIPPO PATHWAY; BETA-CELLS; APOPTOSIS; PROTECTS; DYSFUNCTION; INHIBITION;
D O I：
10.1016/j.ijbiomac.2023.124296
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Major heart diseases pose a serious threat to human health. Finding early diagnostic markers and key therapeutic targets is an urgent scientific problem in this field. Mammalian sterile 20-like kinase 1 (MST1) is a protein kinase, and the occurrence of many heart diseases is related to the continuous activation of the MST1 gene. With the deepening of the research, the potential role of MST1 in promoting the development of heart disease has become more apparent. Therefore, to better understand the role of MST1 in the pathogenesis of heart disease, this work systematically summarizes the role of MST1 in the pathogenesis of heart disease, gives a comprehensive overview of its possible strategies in the diagnosis and treatment of heart disease, and analyzes its potential significance as a marker for the diagnosis and treatment of heart disease.
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收藏
页数：10
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