The Importance of New EBMT Criteria on the Diagnosis of Veno-Occlusive Liver Disease in Children

被引:4
作者
Fussiova, Maria [1 ]
Svec, Peter [1 ]
Horakova, Julia [1 ]
Sedlacek, Petr [2 ]
Rohon, Peter [3 ]
Celec, Peter [4 ]
Bod'ova, Ivana [1 ]
Adamcakova, Jaroslava [1 ]
Sykora, Tomas [1 ]
Dobsinska, Veronika [1 ]
Pozdechova, Miroslava [1 ]
Doczyova, Dominika [1 ]
Vargova, Santia [1 ]
Kolenova, Alexandra [1 ]
机构
[1] Comenius Univ, Natl Inst Childrens Dis, Dept Pediat Hematol & Oncol, Bone Marrow Transplantat Unit, Bratislava 83340, Slovakia
[2] Charles Univ Motol, Dept Pediat Hematol & Oncol, Prague 15006, Czech Republic
[3] Comenius Univ, Fac Med, Dept Hematol & Transfus, Bratislava 81250, Slovakia
[4] Comenius Univ, Inst Mol Biomed, Fac Med, Bratislava 81108, Slovakia
关键词
veno-occlusive disease of the liver; hematopoietic stem cell transplantation; new diagnostic and severity EBMT criteria in childhood; retrospective analysis; SINUSOIDAL OBSTRUCTION SYNDROME; STEM-CELL TRANSPLANTATION; SYNDROME/VENO-OCCLUSIVE DISEASE; BONE-MARROW-TRANSPLANTATION; EUROPEAN-SOCIETY; DEFIBROTIDE; BLOOD; REFRACTORINESS; CLASSIFICATION; COMPLICATIONS;
D O I
10.3390/jcm12030826
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Early recognition and specific therapy facilitate a favorable disease course in hepatic venous-occlusive disease (HVOD) following hematopoietic stem cell transplantation (HCT). Diagnostic and classification criteria, published by the European Society for Blood and Marrow Transplantation (EBMT), better account for clinical differences in disease presentation in pediatric populations. Objectives: To compare the course of HVOD in children before and after the implementation of new EBMT criteria. Material and methods: The study retrospectively evaluates 26 HVODs in 179 children treated in a single HCT unit (Slovakia) comparing the period of 2014-2017 using the Baltimore and modified Seattle criteria with the period of 2018-2021, when new EBMT criteria were adopted. Results: No difference in HVOD incidence (11.2% vs. 14.8%, p = 0.46) and in time of diagnosis post-HCT (15.6 days vs. 15.7 days, p = 0.75) was found. With EBMT criteria we observed more frequent anicteric disease at diagnosis (50% vs. 87.5%, p = 0.04), lower serum bilirubin at diagnosis (3.4 mg/dL vs. 1.23 mg/dL, p = 0.045), and non-significant trends of shorter defibrotide treatment (21.7 days vs. 15.6 days, p = 0.73), decreased mortality (30% vs. 6.2%, p = 0.10) and shorter hospitalization (73.1 days vs. 59.6 days, p = 0.54). Conclusions: Different time periods around the implementation of new criteria are evaluated, underling that pediatric EBMT criteria for post-transplant HVOD diagnosis appear more sensitive.
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页数:15
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