Resident memory T cells develop regional dialects

被引：2
作者：
Maurice, Nicholas J. [1 ]
Jameson, Stephen C. [1 ]
机构：
[1] Univ Minnesota, Ctr Immunol, Med Sch, Minneapolis, MN 55455 USA
来源：
NATURE IMMUNOLOGY | 2023年 / 24卷 / 02期
关键词：
D O I：
10.1038/s41590-022-01416-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human resident memory T (T-RM) cells clonally segregate in distinct tissues, with gene expression signatures tailored to those sites. Hence, beyond a shared language of residency, T-RM cells may acquire local dialects to provide site-specific immunity.
引用
收藏
页码：209 / 210
页数：2
相关论文
共 12 条
  • [1] NicheNet: modeling intercellular communication by linking ligands to target genes
    Browaeys, Robin
    Saelens, Wouter
    Saeys, Yvan
    [J]. NATURE METHODS, 2020, 17 (02) : 159 - +
  • [2] Cross-tissue immune cell analysis reveals tissue-specific features in humans
    Conde, C. Dominguez
    Xu, C.
    Jarvis, L. B.
    Rainbow, D. B.
    Wells, S. B.
    Gomes, T.
    Howlett, S. K.
    Suchanek, O.
    Polanski, K.
    King, H. W.
    Mamanova, L.
    Huang, N.
    Szabo, P. A.
    Richardson, L.
    Bolt, L.
    Fasouli, E. S.
    Mahbubani, K. T.
    Prete, M.
    Tuck, L.
    Richoz, N.
    Tuong, Z. K.
    Campos, L.
    Mousa, H. S.
    Needham, E. J.
    Pritchard, S.
    Li, T.
    Elmentaite, R.
    Park, J.
    Rahmani, E.
    Chen, D.
    Menon, D. K.
    Bayraktar, O. A.
    James, L. K.
    Meyer, K. B.
    Yosef, N.
    Clatworthy, M. R.
    Sims, P. A.
    Farber, D. L.
    Saeb-Parsy, K.
    Jones, J. L.
    Teichmann, S. A.
    [J]. SCIENCE, 2022, 376 (6594) : 713 - +
  • [3] Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments
    Crowl, John T.
    Heeg, Maximilian
    Ferry, Amir
    Milner, J. Justin
    Omilusik, Kyla D.
    Toma, Clara
    He, Zhaoren
    Chang, John T.
    Goldrath, Ananda W.
    [J]. NATURE IMMUNOLOGY, 2022, 23 (07) : 1121 - +
  • [4] Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells
    Fonseca, Raissa
    Burn, Thomas N.
    Gandolfo, Luke C.
    Devi, Sapna
    Park, Simone L.
    Obers, Andreas
    Evrard, Maximilien
    Christo, Susan N.
    Buquicchio, Frank A.
    Lareau, Caleb A.
    McDonald, Keely M.
    Sandford, Sarah K.
    Zamudio, Natasha M.
    Zanluqui, Nagela G.
    Zaid, Ali
    Speed, Terence P.
    Satpathy, Ansuman T.
    Mueller, Scott N.
    Carbone, Francis R.
    Mackay, Laura K.
    [J]. NATURE IMMUNOLOGY, 2022, 23 (08) : 1236 - +
  • [5] Understanding Subset Diversity in T Cell Memory
    Jameson, Stephen C.
    Masopust, David
    [J]. IMMUNITY, 2018, 48 (02) : 214 - 226
  • [6] Fast, sensitive and accurate integration of single-cell data with Harmony
    Korsunsky, Ilya
    Millard, Nghia
    Fan, Jean
    Slowikowski, Kamil
    Zhang, Fan
    Wei, Kevin
    Baglaenko, Yuriy
    Brenner, Michael
    Loh, Po-ru
    Raychaudhuri, Soumya
    [J]. NATURE METHODS, 2019, 16 (12) : 1289 - +
  • [7] Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites
    Kumar, Brahma V.
    Ma, Wenji
    Miron, Michelle
    Granot, Tomer
    Guyer, Rebecca S.
    Carpenter, Dustin J.
    Senda, Takashi
    Sun, Xiaoyun
    Ho, Siu-Hong
    Lerner, Harvey
    Friedman, Amy L.
    Shen, Yufeng
    Farber, Donna L.
    [J]. CELL REPORTS, 2017, 20 (12): : 2921 - 2934
  • [8] Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
    Milner, J. Justin
    Toma, Clara
    Yu, Bingfei
    Zhang, Kai
    Omilusik, Kyla
    Phan, Anthony T.
    Wang, Dapeng
    Getzler, Adam J.
    Nguyen, Toan
    Crotty, Shane
    Wang, Wei
    Pipkin, Matthew E.
    Goldrath, Ananda W.
    [J]. NATURE, 2017, 552 (7684) : 253 - +
  • [9] Tissue adaptation and clonal segregation of human memory T cells in barrier sites
    Poon, Maya M. L.
    Caron, Daniel P. P.
    Wang, Zicheng
    Wells, Steven B. B.
    Chen, David
    Meng, Wenzhao
    Szabo, Peter A. A.
    Lam, Nora
    Kubota, Masaru
    Matsumoto, Rei
    Rahman, Adeeb
    Prak, Eline T. Luning T.
    Shen, Yufeng
    Sims, Peter A. A.
    Farber, Donna L. L.
    [J]. NATURE IMMUNOLOGY, 2023, 24 (02) : 309 - +
  • [10] Tabula Sapiens C., 2022, SCIENCE, V376, peabl4896, DOI [10.1126/science.abl4896, DOI 10.1126/SCIENCE.ABL4896]
12