Prognostic Nomogram for Colorectal Cancer Patients After Surgery

被引：0

作者：

Zhong, Pengqiang ^{[1
]}

Wu, Jiali ^{[1
]}

Yan, Xingxing ^{[2
]}

Liu, Yin ^{[1
]}

Wang, Ruizhi ^{[1
]}

Wang, Dong ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Lab, 58 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China

[2] Guangzhou Univ Tradit Chinese Med, Tradit Chinese Med Hosp Guangdong Prov, Guangzhou 510000, Peoples R China

来源：

INDIAN JOURNAL OF SURGERY | 2023年 / 85卷 / 05期

关键词：

Colorectal cancer; CA125; Prognosis; Nomogram; SURVIVAL; STAGE; BIOMARKERS; SYSTEM; CA125; CEA;

D O I：

10.1007/s12262-023-03712-4

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

To construct a nomogram for overall survival (OS) in colorectal cancer. Using Cox univariate and multivariate analysis, significant variables were plotted into a nomogram. The predictive accuracy and discriminative ability of the nomogram was determined using the concordance index (C-index), receiver operator characteristic curve and calibration curve. CA125 and tumor node metastasis (TNM) were identified as independent predictors for OS in colorectal cancer patients. Area under the curve (AUC) for 1, 3, and 5 years was 0.89, 0.723, and 0.71 respectively in primary cohort, and C-index was 0.702 (95% CI, 0.610 to 0.794) in validation cohort, which indicated a middle degree of accuracy. High-quality calibration plots were seen in the OS nomogram models. Age, CA125, and TNM were identified as poor predictors of colorectal cancer. This nomogram is a valuable predictive tool for the prognosis of colorectal cancer.

引用

页码：1184 / 1190

页数：7

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